Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restriction.
Kimberley C W WangJude S MortonSandra T DavidgeAlexander N LarcombeAlan L JamesGraham M DonovanPeter B NoblePublished in: Respirology (Carlton, Vic.) (2017)
The rat model demonstrates that IUGR leads to a more heterogeneous distribution of airway lumen calibre in adulthood with potential implications for bronchoconstriction in human subjects. Together with increased lung macrophages, these findings support a phenotypic shift after IUGR that may impact disease susceptibility.