Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression.

Alexandros PapalamprosMichail G Vailas Konstantinos NtostoglouMaria Lopez ChiloechesStratigoula SakellariouNiki V ChouliariMenelaos G SamarasParaskevi D Veltsista Sofia D P TheodorouAggelos T MargetisAnna BergonziniLysandros KarydakisNatasha HasemakiSophia HavakiIoannis I MoustakasAntonios ChatzigeorgiouTimokratis KaramitrosEleni PatseaChristos KittasAndreas C LazarisEvangelos FelekourasVassilis G Gorgoulis Teresa FrisanIoannis S Pateras

Published in: Cancers (2020)

This study reveals the existence of dysfunctional T lymphocytes with specific spatial distribution, thus opening a new dimension both conceptually and mechanistically in tumor-stroma interaction in PDAC with potential impact on the efficacy of immune-regulatory therapeutic modalities.

Keyphrases

poor prognosis
transcription factor
single cell
human health
binding protein
climate change
nk cells