Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis.
Arnoldo Aquino-GálvezGeorgina González-ÁvilaLaura Lorena Jiménez-SánchezHéctor Aquiles Maldonado-MartínezJosé CisnerosFernanda Toscano-MarquezManuel Castillejos-LópezLuz María Torres-EspíndolaRafael Velázquez-CruzVíctor Hugo Olivera RodríguezEdgar Flores-SotoHéctor Solís-ChagoyánCarlos CabelloJoaquín ZúñigaYair RomeroPublished in: Respiratory research (2019)
This study lends further support to the involvement of hypoxia in the pathogenesis of IPF, and poses HIF-3α expression as a potential negative regulator of these phenomena.