PRRX1-induced epithelial-to-mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis.
Ya-Ping JiangYa-Ling TangSha-Sha WangJia-Shun WuMei ZhangXin PangJing-Biao WuYu ChenYa-Jie TangXin-Hua LiangPublished in: Cell proliferation (2019)
Collectively, our findings showed that the PRRX1/PPARG2/FFAs signalling in SACC was important for accelerating tumour metastasis through the induction of EMT and the metabolic reprogramming of FFAs.