Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs.
Jenny Van DongenGonneke Willemsennull nullEco J C de GeusDorret I BoomsmaMichael C NealePublished in: eLife (2023)
Funding: We acknowledge funding from the National Institute on Drug Abuse grant DA049867, the Netherlands Organization for Scientific Research (NWO): Biobanking and Biomolecular Research Infrastructure (BBMRI-NL, NWO 184.033.111) and the BBRMI-NL-financed BIOS Consortium (NWO 184.021.007), NWO Large Scale infrastructures X-Omics (184.034.019), Genotype/phenotype database for behavior genetic and genetic epidemiological studies (ZonMw Middelgroot 911-09-032); Netherlands Twin Registry Repository: researching the interplay between genome and environment (NWO-Groot 480-15-001/674); the Avera Institute, Sioux Falls (USA) and the National Institutes of Health (NIH R01 HD042157-01A1, MH081802, Grand Opportunity grants 1RC2 MH089951 and 1RC2 MH089995); epigenetic data were generated at the Human Genomics Facility (HuGe-F) at ErasmusMC Rotterdam. Cotinine assaying was sponsored by the Neuroscience Campus Amsterdam. DIB acknowledges the Royal Netherlands Academy of Science Professor Award (PAH/6635).
Keyphrases
- genome wide
- dna methylation
- public health
- copy number
- gene expression
- quality improvement
- single cell
- endothelial cells
- healthcare
- mental health
- electronic health record
- big data
- adverse drug
- smoking cessation
- induced pluripotent stem cells
- emergency department
- pluripotent stem cells
- health information
- social media
- health promotion
- long term care