Higher chlorzoxazone clearance in obese children compared with nonobese peers.

Christina GadeK DalhoffT S PetersenT RiisC SchmeltzE ChabanovaH R ChristensenGerd MikusJ BurhenneJ C HolmH Holst

Published in: British journal of clinical pharmacology (2018)

Oral clearance of CLZ was increased two-fold in obese children vs. nonobese children aged 11-18 years. This indicates an increased CYP2E1 activity of clinical importance, and dose adjustment should be considered for CLZ.

Keyphrases

young adults
adipose tissue
type diabetes
weight loss
bariatric surgery