Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases.
Maria OczkowiczTomasz SzmatołaMałgorzata ŚwiątkiewiczKlaudia Pawlina-TyszkoArtur GurgulTomasz ZąbekPublished in: BMC genomics (2018)
We observed that the addition of cDDGS positively affects the expression of several genes that have been recently proposed as potential targets for the treatment of obesity, diabetes, cardiovascular disease, and Alzheimer's disease (e.g., FASN, AACS, ALAS1, HMGCS1, and VSIG4). Thus, our results support the idea of including cDDGS into the diets of companion animals and humans and encourage research into the bioactive ingredients of cDDGS.
Keyphrases
- cardiovascular disease
- weight loss
- poor prognosis
- type diabetes
- insulin resistance
- genome wide
- cardiovascular risk factors
- genome wide identification
- human health
- bioinformatics analysis
- dna methylation
- cognitive decline
- gene expression
- risk assessment
- body mass index
- skeletal muscle
- transcription factor
- climate change
- replacement therapy
- tissue engineering