When usual care is not so usual: protocol violations and generalisability in a treat-to-target strategy trial in axial spondyloarthritis.
Clementina López MedinaFilip Van Den BoschDésirée Van Der HeijdeMaxime DougadosAnna MoltóPublished in: Arthritis care & research (2024)
Protocol violations in the T2T arm in the TICOSPA trial were frequent, although they did not have an impact on the rate of the primary outcome. The UC group was optimally treated partly explaining the non-achievement of the primary objective in the TICOSPA trial.