Interaction between Epithelial Sodium Channel γ-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in Renal Collecting Duct.

Ali Sassi Yubao WangAlexandra ChassotOlga KomarynetsIsabelle RothValérie OlivierGilles CrambertEva DizinEmilie BoscardinEdith HummlerEric Feraille

Published in: Journal of the American Society of Nephrology : JASN (2020)

Our data reveal the specific coupling between ENaC γ-subunit and claudin-8 expression. This coupling may play an important role in preventing the backflow of reabsorbed solutes and water to the tubular lumen, as well as in coupling paracellular and transcellular sodium permeability.

Keyphrases

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