High- vs. low-dose diclofenac and cardiovascular risks: a target trial emulation.

Morten SchmidtLars Arendt-NielsenEllen-Margrethe HaugeHenrik Toft SørensenLars Pedersen

Published in: European heart journal. Cardiovascular pharmacotherapy (2023)

Initiators of high- and low-dose diclofenac had comparable increased cardiovascular risks. This finding provides evidence against the assumption that low-dose diclofenac is risk-neutral.

Keyphrases

low dose
high dose
human health
study protocol
risk assessment
randomized controlled trial