Decreased Expression of Circulating miR-20a-5p in South African Women with Gestational Diabetes Mellitus.

This study identifies miR-20a-5p as a potential biomarker for GDM in our population. Gene targets of miR-20a-5p regulate a number of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways not related to GDM, suggesting that miR-20a-5p may have limited disease specificity on its own. Such miRNAs may be useful if incorporated into miRNA panels or risk assessment algorithms to identify GDM. Studies with larger samples are required to strengthen the candidacy of miR-20a-5p as a biomarker for GDM and to assess clinical applicability.