The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients.
Chia-Jui HsuLee Chin WongHsin-Pei WangYi-Chun ChungTe-Wei KaoChen-Hsiang WengWen-Chau WuShinn-Forng PengWen-Yih Isaac TsengWang-Tso LeePublished in: Journal of neurodevelopmental disorders (2023)
Treatment-naïve pediatric GTS patients demonstrated increased connectivity within the CSTC circuit as per diffusion spectrum imaging, indicating possible CSTC circuit dysregulation. This finding could also suggest a compensatory change. It thus underscores the necessity of further investigation into the fundamental pathological changes in GTS. Nevertheless, the observed altered connectivity in GTS patients might serve as a potential target for therapeutic intervention.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- randomized controlled trial
- white matter
- resting state
- young adults
- risk assessment
- mass spectrometry
- functional connectivity
- case report
- combination therapy
- climate change
- subarachnoid hemorrhage