S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study.

Fengguang YangYanni DuanYanhu LiDaxue ZhuZhaoheng WangZhangbin LuoYizhi ZhangGuangzhi ZhangXuegang HeXue-Wen Kang

Published in: Molecular medicine (Cambridge, Mass.) (2024)

This study showed that S100A6 expression increased during IDD and promoted NPCs apoptosis by regulating the Wnt/β-catenin signaling pathway, suggesting that S100A6 is a promising new therapeutic target for IDD.

Keyphrases

cell proliferation
stem cells
poor prognosis
endoplasmic reticulum stress