Discovering genes and microRNAs involved in human lung development unveils IGFBP3/miR-34a dynamics and their relevance for alveolar differentiation.
Melissa Acosta-PlasenciaJoan J CastellanoTania DíazYangyi HeRamón M MarradesAlfonso Navarro-RódenasPublished in: Stem cell research & therapy (2024)
The IGFBP3/miR-34a axis restricts IGFBP3 expression in the embryonic undifferentiated lung epithelium, and the progressive downregulation of IGFBP3 during the pseudoglandular stage is required for alveolar differentiation.