Discovering genes and microRNAs involved in human lung development unveils IGFBP3/miR-34a dynamics and their relevance for alveolar differentiation.

Melissa Acosta-PlasenciaJoan J CastellanoTania DíazYangyi HeRamón M MarradesAlfonso Navarro-Ródenas

Published in: Stem cell research & therapy (2024)

The IGFBP3/miR-34a axis restricts IGFBP3 expression in the embryonic undifferentiated lung epithelium, and the progressive downregulation of IGFBP3 during the pseudoglandular stage is required for alveolar differentiation.

Keyphrases

cell proliferation
long non coding rna
poor prognosis
long noncoding rna
multiple sclerosis
signaling pathway
genome wide
binding protein
gene expression