Hinduchelins A-D, Noncytotoxic Catechol Derivatives from Streptoalloteichus hindustanus.
Fei HeHitomi NakamuraShotaro HoshinoJoyce Seow Fong ChinLiang YangHuiping ZhangFumiaki HayashiLeonard KaysserPublished in: Journal of natural products (2018)
Four new catechol derivatives, hinduchelins A-D (1-4), composed of 2,3- dihydroxybenzoic acid, threonine, and decarboxylated phenylalanine, were isolated from Streptoalloteichus hindustanus. Their structures and absolute configurations were elucidated by interpretation of NMR and HRMS data and quantum chemical ECD calculations. The iron-binding properties of the compounds were evaluated by a pyoverdine production assay in Pseudomonas aeruginosa, and compound 4 showed moderate ability to induce pyoverdine production at 50 μM. None of the compounds were cytotoxic toward HL-20, A549, SMMC-7721, MCF-7, and SW-480 tumor cell lines.
Keyphrases
- pseudomonas aeruginosa
- molecular dynamics
- high resolution
- magnetic resonance
- cystic fibrosis
- density functional theory
- high throughput
- electronic health record
- breast cancer cells
- structure activity relationship
- molecular dynamics simulations
- big data
- monte carlo
- high intensity
- biofilm formation
- protein kinase
- machine learning
- acinetobacter baumannii
- escherichia coli
- solid state
- transcription factor
- staphylococcus aureus
- quantum dots
- deep learning
- data analysis