Leonard Kaysser (Ikuro Abe)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 100

Top Venues

Organic letters

Nature communications

Angewandte Chemie (International ed. in English)

Journal of the American Chemical Society

The University of Tokyo

The University of Tokyo (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

The University of Tokyo May 01 2009

Japan

Professor

Education History

The University of Tokyo Apr 01 1986 - Mar 31 1989

Japan

PHD

The University of Tokyo Apr 01 1984 - Mar 31 1986

Japan

MSC

The University of Tokyo Apr 01 1979 - Mar 31 1984

Japan

BSC

Publications

Takahiro Mori, Leonard Kaysser
Lincosamide Antibiotics: Structure, Activity, and Biosynthesis. Chembiochem : a European journal of chemical biology (2024)
Lu Zhou, Takayoshi Awakawa, Richiro Ushimaru, Masahiro Kanaida, Leonard Kaysser
Characterization of Aziridine-Forming α-Ketoglutarate-Dependent Oxygenase in l-Isovaline Biosynthesis. Organic letters (2024)
Takahiro Mori, Leonard Kaysser
Lincosamide Antibiotics: Structure, Activity, and Biosynthesis. Chembiochem : a European journal of chemical biology 25 (6) (2024)
Yaojie Gao, Yuhao Zhu, Takayoshi Awakawa, Leonard Kaysser
Unusual cysteine modifications in natural product biosynthesis. RSC chemical biology 5 (4) (2024)
Ling-Hong Meng, Takayoshi Awakawa, Xiao-Ming Li, Zhiyang Quan, Sui-Qun Yang, Bin-Gui Wang, Leonard Kaysser
Discovery of (±)-Penindolenes Reveals an Unusual Indole Ring Cleavage Pathway Catalyzed by P450 Monooxygenase. Angewandte Chemie (International ed. in English) (2024)
Huibin Wang, Leonard Kaysser
Recent developments in the enzymatic modifications of steroid scaffolds. Organic & biomolecular chemistry 22 (18) (2024)
Lu Zhou, Takayoshi Awakawa, Richiro Ushimaru, Masahiro Kanaida, Leonard Kaysser
Characterization of Aziridine-Forming α-Ketoglutarate-Dependent Oxygenase in l-Isovaline Biosynthesis. Organic letters 26 (3) (2024)
Shao-Yang Li, Gao-Qian Wang, Liang Long, Jia-Ling Gao, Zheng-Qun Zhou, Yong-Heng Wang, Jian-Ming Lv, Guo-Dong Chen, Dan Hu, Leonard Kaysser, Hao Gao
Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines. Nature communications 15 (1) (2024)
Shao-Yang Li, Gao-Qian Wang, Liang Long, Jia-Ling Gao, Zheng-Qun Zhou, Yong-Heng Wang, Jian-Ming Lv, Guo-Dong Chen, Dan Hu, Leonard Kaysser, Hao Gao
Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines. Nature communications 15 (1) (2024)
Takahiro Mori, Leonard Kaysser
Lincosamide Antibiotics: Structure, Activity, and Biosynthesis. Chembiochem : a European journal of chemical biology 25 (6) (2024)
Zhi-Qin Cao, Gao-Qian Wang, Rui Luo, Yao-Hui Gao, Jian-Ming Lv, Sheng-Ying Qin, Guo-Dong Chen, Takayoshi Awakawa, Xue-Feng Bao, Qing-Hua Mei, Xin-Sheng Yao, Dan Hu, Leonard Kaysser, Hao Gao
Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C-C Bond Cleavage. Journal of the American Chemical Society 146 (18) (2024)
Huibin Wang, Leonard Kaysser
Recent developments in the enzymatic modifications of steroid scaffolds. Organic & biomolecular chemistry 22 (18) (2024)
Takahiro Mori, Leonard Kaysser
Lincosamide Antibiotics: Structure, Activity, and Biosynthesis. Chembiochem : a European journal of chemical biology 25 (6) (2024)
Lu Zhou, Takayoshi Awakawa, Richiro Ushimaru, Masahiro Kanaida, Leonard Kaysser
Characterization of Aziridine-Forming α-Ketoglutarate-Dependent Oxygenase in l-Isovaline Biosynthesis. Organic letters 26 (3) (2024)
Huibin Wang, Leonard Kaysser
Recent developments in the enzymatic modifications of steroid scaffolds. Organic & biomolecular chemistry (2024)
Ling-Hong Meng, Takayoshi Awakawa, Xiao-Ming Li, Zhiyang Quan, Sui-Qun Yang, Bin-Gui Wang, Leonard Kaysser
Discovery of (±)-Penindolenes Reveals an Unusual Indole Ring Cleavage Pathway Catalyzed by P450 Monooxygenase. Angewandte Chemie (International ed. in English) 63 (26) (2024)
Yaojie Gao, Yuhao Zhu, Takayoshi Awakawa, Leonard Kaysser
Unusual cysteine modifications in natural product biosynthesis. RSC chemical biology 5 (4) (2024)
Shao-Yang Li, Gao-Qian Wang, Liang Long, Jia-Ling Gao, Zheng-Qun Zhou, Yong-Heng Wang, Jian-Ming Lv, Guo-Dong Chen, Dan Hu, Leonard Kaysser, Hao Gao
Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines. Nature communications 15 (1) (2024)
Huibin Wang, Leonard Kaysser
Recent developments in the enzymatic modifications of steroid scaffolds. Organic & biomolecular chemistry 22 (18) (2024)
Shotaro Hoshino, Hiroyasu Onaka, Leonard Kaysser
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products. Natural product reports (2024)
Ling-Hong Meng, Takayoshi Awakawa, Xiao-Ming Li, Zhiyang Quan, Sui-Qun Yang, Bin-Gui Wang, Leonard Kaysser
Discovery of (±)-Penindolenes Reveals an Unusual Indole Ring Cleavage Pathway Catalyzed by P450 Monooxygenase. Angewandte Chemie (International ed. in English) 63 (26) (2024)
Zhi-Qin Cao, Gao-Qian Wang, Rui Luo, Yao-Hui Gao, Jian-Ming Lv, Sheng-Ying Qin, Guo-Dong Chen, Takayoshi Awakawa, Xue-Feng Bao, Qing-Hua Mei, Xin-Sheng Yao, Dan Hu, Leonard Kaysser, Hao Gao
Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C-C Bond Cleavage. Journal of the American Chemical Society (2024)
Lu Zhou, Takayoshi Awakawa, Richiro Ushimaru, Masahiro Kanaida, Leonard Kaysser
Characterization of Aziridine-Forming α-Ketoglutarate-Dependent Oxygenase in l-Isovaline Biosynthesis. Organic letters 26 (3) (2024)
Yern-Hyerk Shin, Ji Hyeon Im, Ilnam Kang, Eunji Kim, Sung Chul Jang, Eunji Cho, Daniel Shin, Sunghoon Hwang, Young Eun Du, Thanh-Hau Huynh, Keebeom Ko, Yoon-Joo Ko, Sang-Jip Nam, Takayoshi Awakawa, Jeeyeon Lee, Suckchang Hong, Leonard Kaysser, Bradley S Moore, William Fenical, Yeo Joon Yoon, Jang-Cheon Cho, Sang-Kook Lee, Ki-Bong Oh, Dong-Chan Oh
Genomic and Spectroscopic Signature-Based Discovery of Natural Macrolactams. Journal of the American Chemical Society (2023)
Richiro Ushimaru, Leonard Kaysser
Back-to-back cycloadditions in nature. Nature chemistry (2023)
Yern-Hyerk Shin, Ji Hyeon Im, Ilnam Kang, Eunji Kim, Sung Chul Jang, Eunji Cho, Daniel Shin, Sunghoon Hwang, Young Eun Du, Thanh-Hau Huynh, Keebeom Ko, Yoon-Joo Ko, Sang-Jip Nam, Takayoshi Awakawa, Jeeyeon Lee, Suckchang Hong, Leonard Kaysser, Bradley S Moore, William Fenical, Yeo Joon Yoon, Jang-Cheon Cho, Sang-Kook Lee, Ki-Bong Oh, Dong-Chan Oh
Genomic and Spectroscopic Signature-Based Discovery of Natural Macrolactams. Journal of the American Chemical Society 145 (3) (2023)
Richiro Ushimaru, Lide Cha, Shotaro Shimo, Xiaojun Li, Jared C Paris, Takahiro Mori, Kazunori Miyamoto, Lindsay Coffer, Masanobu Uchiyama, Yisong Guo, Wei-Chen Chang, Leonard Kaysser
Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes. Journal of the American Chemical Society (2023)
Richiro Ushimaru, Yiling Ding, Takahiro Mori, Kazunori Miyamoto, Masanobu Uchiyama, Leonard Kaysser
Structural and Mechanistic Insights into the C-C Bond-Forming Rearrangement Reaction Catalyzed by Heterodimeric Hinokiresinol Synthase. Journal of the American Chemical Society (2023)
Yern-Hyerk Shin, Ji Hyeon Im, Ilnam Kang, Eunji Kim, Sung Chul Jang, Eunji Cho, Daniel Shin, Sunghoon Hwang, Young Eun Du, Thanh-Hau Huynh, Keebeom Ko, Yoon-Joo Ko, Sang-Jip Nam, Takayoshi Awakawa, Jeeyeon Lee, Suckchang Hong, Leonard Kaysser, Bradley S Moore, William Fenical, Yeo Joon Yoon, Jang-Cheon Cho, Sang-Kook Lee, Ki-Bong Oh, Dong-Chan Oh
Genomic and Spectroscopic Signature-Based Discovery of Natural Macrolactams. Journal of the American Chemical Society 145 (3) (2023)
Richiro Ushimaru, Jiaqi Lyu, Meiqi Ling, Leonard Kaysser
Multiple C-C Bond Cleavage Reactions Catalyzed by Tolyporphin Tetrapyrrole Biosynthetic Enzymes. Journal of the American Chemical Society (2023)
Yern-Hyerk Shin, Ji Hyeon Im, Ilnam Kang, Eunji Kim, Sung Chul Jang, Eunji Cho, Daniel Shin, Sunghoon Hwang, Young Eun Du, Thanh-Hau Huynh, Keebeom Ko, Yoon-Joo Ko, Sang-Jip Nam, Takayoshi Awakawa, Jeeyeon Lee, Suckchang Hong, Leonard Kaysser, Bradley S Moore, William Fenical, Yeo Joon Yoon, Jang-Cheon Cho, Sang-Kook Lee, Ki-Bong Oh, Dong-Chan Oh
Genomic and Spectroscopic Signature-Based Discovery of Natural Macrolactams. Journal of the American Chemical Society 145 (3) (2023)
Richiro Ushimaru, Leonard Kaysser
Assembling neuroactive alkaloids. Nature plants (2023)
Richiro Ushimaru, Jiaqi Lyu, Leonard Kaysser
Diverse enzymatic chemistry for propionate side chain cleavages in tetrapyrrole biosynthesis. Journal of industrial microbiology & biotechnology (2023)
Takayoshi Awakawa, Takahiro Mori, Richiro Ushimaru, Leonard Kaysser
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis. Natural product reports (2022)
Takahiro Mori, Yu Nakashima, Heping Chen, Shotaro Hoshino, Takaaki Mitsuhashi, Leonard Kaysser
Structure-based redesign of Fe(II)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation. Chemical communications (Cambridge, England) 58 (36) (2022)
Xiao-Hui Wang, Bo-Wen Gao, Yu Nakashima, Takahiro Mori, Zhong-Xiu Zhang, Takeshi Kodama, Yuan-E Lee, Ze-Kun Zhang, Chin-Piow Wong, Qian-Qian Liu, Bo-Wen Qi, Juan Wang, Jun Li, Xiao Liu, Leonard Kaysser, Hiroyuki Morita, Peng-Fei Tu, She-Po Shi
Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood. Nature communications 13 (1) (2022)
Xinyang Li, He-Ping Chen, Lin Zhou, Jing Fan, Takayoshi Awakawa, Takahiro Mori, Richiro Ushimaru, Leonard Kaysser, Ji-Kai Liu
Cordycicadins A-D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1. Organic letters 24 (47) (2022)
Hui Tao, Takahiro Mori, Heping Chen, Shuang Lyu, Akihito Nonoyama, Shoukou Lee, Leonard Kaysser
Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF. Nature communications 13 (1) (2022)
Bo-Wen Qi, Na Li, Bei-Bei Zhang, Ze-Kun Zhang, Wen-Jing Wang, Xiao Liu, Juan Wang, Takayoshi Awakawa, Peng-Fei Tu, Leonard Kaysser, She-Po Shi, Jun Li
A Multifunctional Cytochrome P450 and a Meroterpenoid Cyclase in the Biosynthesis of Fungal Meroterpenoid Atlantinone B. Organic letters 24 (13) (2022)
Lena Barra, Takayoshi Awakawa, Leonard Kaysser
Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis. JACS Au 2 (9) (2022)
Jiaqi Lyu, Richiro Ushimaru, Leonard Kaysser
Characterization of Enzymes Catalyzing the Initial Steps of the β-Lactam Tabtoxin Biosynthesis. Organic letters 24 (18) (2022)
Takahiro Mori, Ziheng Yu, Hui Tao, Leonard Kaysser
Rational Engineering of the Nonheme Iron- and 2-Oxoglutarate-Dependent Oxygenase SptF. Organic letters 24 (8) (2022)
Hui Tao, Lukas Lauterbach, Guangkai Bian, Rong Chen, Anwei Hou, Takahiro Mori, Shu Cheng, Ben Hu, Li Lu, Xin Mu, Min Li, Naruhiko Adachi, Masato Kawasaki, Toshio Moriya, Toshiya Senda, Xing-Huan Wang, Zixin Deng, Leonard Kaysser, Jeroen S Dickschat, Tian-Gang Liu
Discovery of non-squalene triterpenes. Nature 606 (7913) (2022)
Takahiro Mori, Leonard Kaysser
Structural basis for endoperoxide-forming oxygenases. Beilstein journal of organic chemistry 18 (2022)
Hui Tao, Richiro Ushimaru, Takayoshi Awakawa, Takahiro Mori, Masanobu Uchiyama, Leonard Kaysser
Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaL. Journal of the American Chemical Society 144 (47) (2022)
Takayoshi Awakawa, Leonard Kaysser
Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae. Journal of fungi (Basel, Switzerland) 7 (6) (2021)
Takahiro Jomori, Kenichi Matsuda, Yoko Egami, Leonard Kaysser, Akira Takai, Toshiyuki Wakimoto
Insights into phosphatase-activated chemical defense in a marine sponge holobiont. RSC chemical biology 2 (6) (2021)
Shotaro Shimo, Richiro Ushimaru, Alicia Engelbrecht, Mei Harada, Kazunori Miyamoto, Andreas Kulik, Masanobu Uchiyama, Leonard Kaysser, Leonard Kaysser
Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins. Journal of the American Chemical Society 143 (44) (2021)
Reito Bunno, Takayoshi Awakawa, Takahiro Mori, Leonard Kaysser
Aziridine Formation by a FeII /α-Ketoglutarate Dependent Oxygenase and 2-Aminoisobutyrate Biosynthesis in Fungi. Angewandte Chemie (International ed. in English) 60 (29) (2021)
Lena Barra, Takayoshi Awakawa, Kohei Shirai, Zhijuan Hu, Ghader Bashiri, Leonard Kaysser
β-NAD as a building block in natural product biosynthesis. Nature (2021)
Takahiro Mori, Takuto Kumano, Haibing He, Satomi Watanabe, Miki Senda, Toshio Moriya, Naruhiko Adachi, Sanae Hori, Yuzu Terashita, Masato Kawasaki, Yoshiteru Hashimoto, Takayoshi Awakawa, Toshiya Senda, Leonard Kaysser, Michihiko Kobayashi
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes. Nature communications 12 (1) (2021)
Takayoshi Awakawa, Lena Barra, Leonard Kaysser
Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete. Journal of industrial microbiology & biotechnology 48 (3-4) (2021)
Xinyang Li, Takayoshi Awakawa, Takahiro Mori, Meiqi Ling, Dan Hu, Bin Wu, Leonard Kaysser
Heterodimeric Non-heme Iron Enzymes in Fungal Meroterpenoid Biosynthesis. Journal of the American Chemical Society (2021)
Hui Tao, Takahiro Mori, Xingxing Wei, Yudai Matsuda, Leonard Kaysser
One Polyketide Synthase, Two Distinct Products: Trans-Acting Enzyme-Controlled Product Divergence in Calbistrin Biosynthesis. Angewandte Chemie (International ed. in English) 60 (16) (2021)
Takahiro Mori, Rui Zhai, Richiro Ushimaru, Yudai Matsuda, Leonard Kaysser
Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI. Nature communications 12 (1) (2021)
Jiali Yang, Takahiro Mori, Xingxing Wei, Yudai Matsuda, Leonard Kaysser
Structural Basis for Isomerization Reactions in Fungal Tetrahydroxanthone Biosynthesis and Diversification. Angewandte Chemie (International ed. in English) 60 (35) (2021)
Juan Wang, Ze-Kun Zhang, Fang-Fang Jiang, Bo-Wen Qi, Ning Ding, Saw Yu Yu Hnin, Xiao Liu, Jun Li, Xiao-Hui Wang, Peng-Fei Tu, Leonard Kaysser, Hiroyuki Morita, She-Po Shi
Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis. Organic letters 22 (21) (2020)
Xinyang Li, Jian-Ming Lv, Dan Hu, Leonard Kaysser
Biosynthesis of alkyne-containing natural products. RSC chemical biology 2 (1) (2020)
Ryosuke Kozakai, Takuto Ono, Shotaro Hoshino, Hidenori Takahashi, Yohei Katsuyama, Yoshinori Sugai, Taro Ozaki, Kazuya Teramoto, Kanae Teramoto, Koichi Tanaka, Leonard Kaysser, Shumpei Asamizu, Hiroyasu Onaka
Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides. Nature chemistry 12 (9) (2020)
Tongxuan Bai, Yudai Matsuda, Hui Tao, Takahiro Mori, Yong-Hui Zhang, Leonard Kaysser
Structural Diversification of Andiconin-Derived Natural Products by α-Ketoglutarate-Dependent Dioxygenases. Organic letters 22 (11) (2020)
Iori Morita, Takahiro Mori, Takaaki Mitsuhashi, Shotaro Hoshino, Yoshimasa Taniguchi, Takashi Kikuchi, Kei Nagae, Norihiro Nasu, Makoto Fujita, Tomohiko Ohwada, Leonard Kaysser
Exploiting a C-N Bond Forming Cytochrome P450 Monooxygenase for C-S Bond Formation. Angewandte Chemie (International ed. in English) 59 (10) (2020)
Leonard Kaysser
Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases. Journal of natural medicines 74 (4) (2020)
Jian-Ming Lv, Yao-Hui Gao, Huan Zhao, Takayoshi Awakawa, Ling Liu, Guo-Dong Chen, Xin-Sheng Yao, Dan Hu, Leonard Kaysser, Hao Gao
Biosynthesis of Biscognienyne B Involving a Cytochrome P450-Dependent Alkynylation. Angewandte Chemie (International ed. in English) 59 (32) (2020)
Iori Morita, Takahiro Mori, Leonard Kaysser
Enzymatic Formation of Indolactam Scaffold by C-N Bond-Forming Cytochrome P450 Oxidases in Teleocidin Biosynthesis. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (9) (2020)
Takaaki Mitsuhashi, Lena Barra, Zachary Powers, Volga Kojasoy, Andrea Cheng, Feng Yang, Yoshimasa Taniguchi, Takashi Kikuchi, Makoto Fujita, Dean J Tantillo, John A Porco, Leonard Kaysser
Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids. Angewandte Chemie (International ed. in English) 59 (52) (2020)
Yue-Hong Zhang, Yi-Fang Li, Yongjin Wang, Li Tan, Zhi-Qin Cao, Chao Xie, Guo Xie, Hai-Biao Gong, Wan-Yang Sun, Shu-Hua Ouyang, Wen-Jun Duan, Xiaoyun Lu, Ke Ding, Hiroshi Kurihara, Dan Hu, Zhi-Min Zhang, Leonard Kaysser, Rong-Rong He
Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nature communications 11 (1) (2020)
Haibing He, Guangkai Bian, Corey J Herbst-Gervasoni, Takahiro Mori, Stephen A Shinsky, Anwei Hou, Xin Mu, Minjian Huang, Shu Cheng, Zixin Deng, David W Christianson, Leonard Kaysser, Tian-Gang Liu
Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases. Nature communications 11 (1) (2020)
Yasuko Araki, Takayoshi Awakawa, Motomichi Matsuzaki, Rihe Cho, Yudai Matsuda, Shotaro Hoshino, Yasutomo Shinohara, Masaichi Yamamoto, Yasutoshi Kido, Daniel Ken Inaoka, Kisaburo Nagamune, Kotaro Ito, Leonard Kaysser, Kiyoshi Kita
Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum. Proceedings of the National Academy of Sciences of the United States of America 116 (17) (2019)
Zachary Powers, Adam Scharf, Andrea Cheng, Feng Yang, Martin Himmelbauer, Takaaki Mitsuhashi, Lena Barra, Yoshimasa Taniguchi, Takashi Kikuchi, Makoto Fujita, Leonard Kaysser, John A Porco
Biomimetic Synthesis of Meroterpenoids by Dearomatization-Driven Polycyclization. Angewandte Chemie (International ed. in English) 58 (45) (2019)
Takayoshi Awakawa, Leonard Kaysser
Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis. Beilstein journal of organic chemistry 15 (2019)
Zhiyang Quan, Takayoshi Awakawa, Dongmei Wang, Yue Hu, Leonard Kaysser
Multidomain P450 Epoxidase and a Terpene Cyclase from the Ascochlorin Biosynthetic Pathway in Fusarium sp. Organic letters 21 (7) (2019)
Zhijuan Hu, Takayoshi Awakawa, Zhongjun Ma, Leonard Kaysser
Aminoacyl sulfonamide assembly in SB-203208 biosynthesis. Nature communications 10 (1) (2019)
Shotaro Hoshino, Takaaki Mitsuhashi, Takashi Kikuchi, Chin Piow Wong, Hiroyuki Morita, Takayoshi Awakawa, Makoto Fujita, Leonard Kaysser
Structural Elucidation of Tenebrathin: Cytotoxic C-5-Substituted γ-Pyrone with a Nitroaryl Side Chain from Streptoalloteichus tenebrarius. Organic letters 21 (16) (2019)
Fei He, Takahiro Mori, Iori Morita, Hitomi Nakamura, Miroslava Alblova, Shotaro Hoshino, Takayoshi Awakawa, Leonard Kaysser
Molecular basis for the P450-catalyzed C-N bond formation in indolactam biosynthesis. Nature chemical biology 15 (12) (2019)
Hiroyuki Morita, Chin Piow Wong, Leonard Kaysser
How structural subtleties lead to molecular diversity for the type III polyketide synthases. The Journal of biological chemistry 294 (41) (2019)
Lu-Lin Xu, Hai-Li Chen, Ping Hai, Yuan Gao, Chuan-Dong Xie, Xiao-Long Yang, Leonard Kaysser
(+)- and (-)-Preuisolactone A: A Pair of Caged Norsesquiterpenoidal Enantiomers with a Tricyclo[4.4.01,6.02,8]decane Carbon Skeleton from the Endophytic Fungus Preussia isomera. Organic letters 21 (4) (2019)
Fei He, Hitomi Nakamura, Shotaro Hoshino, Joyce Seow Fong Chin, Liang Yang, Huiping Zhang, Fumiaki Hayashi, Leonard Kaysser
Hinduchelins A-D, Noncytotoxic Catechol Derivatives from Streptoalloteichus hindustanus. Journal of natural products 81 (6) (2018)
Shotaro Hoshino, Masahiro Ozeki, Takayoshi Awakawa, Hiroyuki Morita, Hiroyasu Onaka, Leonard Kaysser
Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium. Journal of natural products 81 (9) (2018)
Yu Nakashima, Takaaki Mitsuhashi, Yudai Matsuda, Miki Senda, Hajime Sato, Mami Yamazaki, Masanobu Uchiyama, Toshiya Senda, Leonard Kaysser
Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis. Journal of the American Chemical Society 140 (30) (2018)
Takayoshi Awakawa, Takahiro Mori, Yu Nakashima, Rui Zhai, Chin Piow Wong, Matthew L Hillwig, Xinyu Liu, Leonard Kaysser
Molecular Insight into the Mg2+ -Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1. Angewandte Chemie (International ed. in English) 57 (23) (2018)
Shotaro Hoshino, Chin Piow Wong, Masahiro Ozeki, Huiping Zhang, Fumiaki Hayashi, Takayoshi Awakawa, Shumpei Asamizu, Hiroyasu Onaka, Leonard Kaysser
Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium. The Journal of antibiotics 71 (7) (2018)
Tongxuan Bai, Zhiyang Quan, Rui Zhai, Takayoshi Awakawa, Yudai Matsuda, Leonard Kaysser
Elucidation and Heterologous Reconstitution of Chrodrimanin B Biosynthesis. Organic letters 20 (23) (2018)
Tomotoshi Sugita, Masahiro Okada, Yu Nakashima, Tian Tian, Leonard Kaysser
A Tryptophan Prenyltransferase with Broad Substrate Tolerance from Bacillus subtilis subsp. natto. Chembiochem : a European journal of chemical biology 19 (13) (2018)
Hajime Sato, Takaaki Mitsuhashi, Mami Yamazaki, Leonard Kaysser, Masanobu Uchiyama
Computational Studies on Biosynthetic Carbocation Rearrangements Leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Skeleton Type. Angewandte Chemie (International ed. in English) 57 (45) (2018)
Yu Nakashima, Takahiro Mori, Hitomi Nakamura, Takayoshi Awakawa, Shotaro Hoshino, Miki Senda, Toshiya Senda, Leonard Kaysser
Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis. Nature communications 9 (1) (2018)
Gao-Qian Wang, Guo-Dong Chen, Sheng-Ying Qin, Dan Hu, Takayoshi Awakawa, Shao-Yang Li, Jian-Ming Lv, Chuan-Xi Wang, Xin-Sheng Yao, Leonard Kaysser, Hao Gao
Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage. Nature communications 9 (1) (2018)
Yudai Matsuda, Tongxuan Bai, Christopher B W Phippen, Christina S Nødvig, Inge Kjærbølling, Tammi C Vesth, Mikael Rørdam Andersen, Uffe Hasbro Mortensen, Charlotte Held Gotfredsen, Leonard Kaysser, Thomas Ostenfeld Larsen
Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation. Nature communications 9 (1) (2018)
Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Leonard Kaysser
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution. Nature communications 9 (1) (2018)
Takaaki Mitsuhashi, Leonard Kaysser
Chimeric Terpene Synthases Possessing both Terpene Cyclization and Prenyltransfer Activities. Chembiochem : a European journal of chemical biology (2018)
Leonard Kaysser
Biosynthetic studies on teleocidins in Streptomyces. The Journal of antibiotics 71 (9) (2018)
Takaaki Mitsuhashi, Takashi Kikuchi, Shotaro Hoshino, Masahiro Ozeki, Takayoshi Awakawa, She-Po Shi, Makoto Fujita, Leonard Kaysser
Crystalline Sponge Method Enabled the Investigation of a Prenyltransferase-terpene Synthase Chimeric Enzyme, Whose Product Exhibits Broadened NMR Signals. Organic letters 20 (18) (2018)
Shotaro Hoshino, Masahiro Okada, Takayoshi Awakawa, Shumpei Asamizu, Hiroyasu Onaka, Leonard Kaysser
Mycolic Acid Containing Bacterium Stimulates Tandem Cyclization of Polyene Macrolactam in a Lake Sediment Derived Rare Actinomycete. Organic letters 19 (18) (2017)
Takaaki Mitsuhashi, Masahiro Okada, Leonard Kaysser
Identification of Chimeric αβγ Diterpene Synthases Possessing both Type II Terpene Cyclase and Prenyltransferase Activities. Chembiochem : a European journal of chemical biology 18 (21) (2017)
Masahiro Okada, Kai Saito, Chin Piow Wong, Chang Li, Dongmei Wang, Miu Iijima, Futoshi Taura, Fumiya Kurosaki, Takayoshi Awakawa, Leonard Kaysser
Combinatorial Biosynthesis of (+)-Daurichromenic Acid and Its Halogenated Analogue. Organic letters 19 (12) (2017)
Bowen Qi, Xiao Liu, Ting Mo, Zhixiang Zhu, Jun Li, Juan Wang, Xiaoping Shi, Kewu Zeng, Xiaohui Wang, Pengfei Tu, Leonard Kaysser, She-Po Shi
3,5-Dimethylorsellinic Acid Derived Meroterpenoids from Penicillium chrysogenum MT-12, an Endophytic Fungus Isolated from Huperzia serrata. Journal of natural products 80 (10) (2017)
Chin Piow Wong, Takayoshi Awakawa, Yu Nakashima, Takahiro Mori, Qin Zhu, Xinyu Liu, Leonard Kaysser
Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3. Angewandte Chemie (International ed. in English) 57 (2) (2017)
Masahiro Okada, Tomotoshi Sugita, Chin Piow Wong, Toshiyuki Wakimoto, Leonard Kaysser
Identification of Pyridinium with Three Indole Moieties as an Antimicrobial Agent. Journal of natural products 80 (4) (2017)
Lihan Zhang, Takuya Hashimoto, Bin Qin, Junko Hashimoto, Ikuko Kozone, Teppei Kawahara, Masahiro Okada, Takayoshi Awakawa, Takuya Ito, Yoshinori Asakawa, Masashi Ueki, Shunji Takahashi, Hiroyuki Osada, Toshiyuki Wakimoto, Haruo Ikeda, Kazuo Shin-Ya, Leonard Kaysser
Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides. Angewandte Chemie (International ed. in English) 56 (7) (2017)
Miu Iijima, Ryosuke Munakata, Hironobu Takahashi, Hiromichi Kenmoku, Ryuichi Nakagawa, Takeshi Kodama, Yoshinori Asakawa, Leonard Kaysser, Kazufumi Yazaki, Fumiya Kurosaki, Futoshi Taura
Identification and Characterization of Daurichromenic Acid Synthase Active in Anti-HIV Biosynthesis. Plant physiology 174 (4) (2017)
Jian-Ming Lv, Dan Hu, Hao Gao, Tetsuo Kushiro, Takayoshi Awakawa, Guo-Dong Chen, Chuan-Xi Wang, Leonard Kaysser, Xin-Sheng Yao
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis. Nature communications 8 (1) (2017)

Leonard Kaysser.css-eqlu8i{font-size:small;padding-left:4px;} (Ikuro Abe)

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Leonard Kaysser (Ikuro Abe)