3,4- seco-Norclerodane Diterpenoids from the Roots of Polyalthia laui.
Zhang-Xin YuCai-Juan ZhengGuang-Ying ChenRong-Li HuangXue-Ming ZhouZhi-Gang NiuXiao-Bao LiChang-Ri HanXiao-Ping SongPublished in: Journal of natural products (2018)
Ten new clerodane diterpenoids, polylauioids A-J (1-10), and five known analogues (11-15) were isolated from the roots of Polyalthia laui. Among the new compounds, 3 and 8 are artifacts. The structures were elucidated using spectroscopic methods and by comparison with published NMR spectroscopic data. The absolute configurations of 4, 5, and 7 were defined based on single-crystal X-ray diffraction and electronic circular dichroism data. Compounds 1 and 2 represent the first examples of rearranged 3,4- seco-norclerodane diterpenoids, and a putative biosynthesis pathway for these compounds is proposed. Compounds 1, 4, 6, 7, 9, and 10 showed anti-HIV activities with EC50 values ranging from 12.2 to 35.2 μM.
Keyphrases
- molecular docking
- high resolution
- electronic health record
- big data
- antiretroviral therapy
- hiv infected
- human immunodeficiency virus
- randomized controlled trial
- magnetic resonance imaging
- systematic review
- hiv testing
- hiv positive
- hiv aids
- solid state
- machine learning
- molecular dynamics simulations
- computed tomography
- artificial intelligence
- deep learning
- men who have sex with men