Login / Signup

Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity.

Congcong ZhangJasmin RöderAnne SchererMalena BoddenJordi Pfeifer SerrahimaAnita BhattiAnja WaldmannNina MüllerPranav OberoiWinfried S Wels
Published in: Journal for immunotherapy of cancer (2022)
Our results demonstrate that combining an NKAB antibody with effector cells expressing an activating NKAR receptor represents a powerful and versatile approach to simultaneously enhance tumor antigen-specific as well as NKG2D-CAR and natural NKG2D-mediated cytotoxicity, which may be particularly useful to target tumors with heterogeneous target antigen expression.
Keyphrases
  • natural killer cells
  • induced apoptosis
  • poor prognosis
  • signaling pathway
  • cell cycle arrest
  • nk cells
  • binding protein
  • dendritic cells
  • regulatory t cells
  • oxidative stress
  • cell proliferation
  • type iii