The efficacy of vitamin B6 as an adjunctive therapy to lithium in improving the symptoms of acute mania in patients with bipolar disorder, type 1; a double-blind, randomized, placebo-controlled, clinical trial.
Rahim BadrfamSeyed-Ali MostafaviAli KhaleghiShahin AkhondzadehAtefeh ZandifarMalihe FaridNami Mohammadian KhonsariMohammad Reza MohammadiPublished in: Brain and behavior (2021)
According to this study, the daily dose of 80 mg of vitamin B6 for 8 weeks in patients with bipolar disorder in the manic episode with psychotic feature treated daily with lithium, was not associated with a significant improvement in mood status compared to the control-placebo group. It is recommended to perform similar studies in a multi-center manner with a larger sample size and longer duration.
Keyphrases
- bipolar disorder
- double blind
- placebo controlled
- clinical trial
- phase iii
- major depressive disorder
- phase ii
- open label
- study protocol
- physical activity
- liver failure
- phase ii study
- solid state
- deep learning
- machine learning
- respiratory failure
- randomized controlled trial
- intensive care unit
- depressive symptoms
- aortic dissection