Spatial gene expression profiling unveils immuno-oncogenic programs of NF1-associated peripheral nerve sheath tumor progression.
Dana K MitchellBreanne BurgessEmily E WhiteAbbi Elise SmithElizabeth A Sierra PotchanantHenry Elmer MangBrooke E HickeyQingbo LuShaomin QianWaylan BesslerXiaohong LiLi JiangKylee BrewsterConstance J TemmAndrew E HorvaiEric A AlbrightMelissa L FishelChristine A PratilasSteven P AngusD Wade ClappSteven D RhodesPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
If validated prospectively in future studies, these signatures may serve as molecular diagnostic tools to augment conventional histopathological diagnosis by identifying neurofibromas at high risk of undergoing malignant transformation, facilitating risk-adapted care.
Keyphrases
- peripheral nerve
- gene expression
- healthcare
- signaling pathway
- dna methylation
- palliative care
- poor prognosis
- current status
- lps induced
- public health
- quality improvement
- genome wide
- transcription factor
- single cell
- oxidative stress
- pi k akt
- nuclear factor
- case control
- pain management
- long non coding rna
- single molecule
- health insurance