Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non-Small Cell Lung Cancer.
Jiajia ZhangZhicheng JiJustina X CaushiMargueritta El AsmarValsamo AnagnostouTricia R CottrellHok Yee ChanPrerna SuriHaidan GuoTaha MerghoubJamie E ChaftJoshua E ReussAda J TamRichard L BlosserMohsen Abu-AkeelJohn-William SidhomNi ZhaoJinny S HaDavid R JonesKristen A MarroneJarushka NaidooEdward GabrielsonJanis M TaubeVictor E VelculescuJulie R BrahmerFranck HousseauMatthew D HellmannPatrick M FordeDrew M PardollHongkai JiKellie N SmithPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Our study suggests that exchange of T-cell clones between tumor and blood represents a key correlate of pathologic response to neoadjuvant immunotherapy and shows that the periphery may be a previously underappreciated originating compartment for effective antitumor immunity.See related commentary by Henick, p. 1205.