Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain.
Kord M KoberMan-Cheung LeeAdam OlshenYvette P ConleyMarina SirotaMichael KeiserMarilyn J HammerGary AbramsMark SchumacherJon D LevineChristine MiaskowskiPublished in: Molecular pain (2021)
This study is the first to evaluate for methylation in cancer survivors with chronic PIPN. The findings provide evidence that the expression of H1SP genes associated with chronic PIPN in cancer survivors may be regulated by epigenetic mechanisms and suggests genes for validation as potential therapeutic targets.
Keyphrases
- neuropathic pain
- genome wide
- chemotherapy induced
- dna methylation
- poor prognosis
- signaling pathway
- spinal cord
- young adults
- spinal cord injury
- drug induced
- binding protein
- long non coding rna
- childhood cancer
- bioinformatics analysis
- high glucose
- genome wide identification
- stem cells
- oxidative stress
- induced apoptosis
- diabetic rats
- transcription factor
- bone marrow
- human health