Age-related increases in IGFBP2 increase melanoma cell invasion and lipid synthesis.

Gretchen M AliceaMarie E PortualloPayal PatelMitchell E FaneAlexis E CareyDavid SpeicherHsin-Yao TangAndrew V KossenkovVito W RebeccaDenis G WirtzAshani T Weeraratna

Published in: bioRxiv : the preprint server for biology (2023)

The aged microenvironment drives metastasis in melanoma cells. This study reports that IGFBP2 secretion by aged fibroblasts induces FASN in melanoma cells and drives metastasis. Neutralizing IGFBP2 decreases melanoma tumor growth and metastasis.

Keyphrases

stem cells
skin cancer
emergency department
fatty acid
extracellular matrix
dengue virus
adverse drug
zika virus