The impact of intestinal microbiota on weight loss in Parkinson's disease patients: a pilot study.
Federica Del ChiericoPaola GrassiniAndrea QuagliarielloMargherita TortiAlessandra RussoSofia ReddelFabrizio StocchiPublished in: Future microbiology (2021)
Background: There is increasing evidence of the association between microbiome dysfunction and Parkinson's disease (PD). Moreover, some PD patients suffer from unintentional weight loss (WL) which may precede the motor manifestations of the disease. Materials & methods: Gut microbiota profiling by 16S rRNA gene sequencing was performed in PD patients with an unintended WL, in steady weight patients (non-WL [NWL]) and in matched normal subjects. KEGG functional predictions were carried out. Results: Microbiota profiles revealed a dissimilarity between WL and NWL. Moreover, WL pathways were characterized by fatty acid biosynthesis, while NWL by inflammation pathways. Conclusion: The gut microbiota could participate in weight alteration observed in PD by the presence of bacteria involved in weight gain and inflammation, or conversely by bacteria implicated in energy expenditure.
Keyphrases
- weight loss
- weight gain
- end stage renal disease
- ejection fraction
- newly diagnosed
- body mass index
- oxidative stress
- bariatric surgery
- type diabetes
- prognostic factors
- fatty acid
- peritoneal dialysis
- physical activity
- patient reported outcomes
- dna methylation
- transcription factor
- gastric bypass
- insulin resistance
- copy number
- body weight