Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.
Andrew J MenssenAjay KhannaChristopher A MillerSridhar Nonavinkere SrivatsanGue Su ChangJin ShaoJoshua RobinsonMichele O'LaughlinCatrina C FronickRobert S FultonKimberly BrendelSharon E HeathRaya SabaJohn S S WelchDavid H SpencerJacqueline E PaytonPeter WesterveltJohn F DiPersioDaniel C LinkMatthew J SchuelkeMeagan A JacobyEric J DuncavageTimothy J LeyMatthew J WalterPublished in: Blood cancer discovery (2022)
Subclone expansion is a hallmark of progression from MDS to secondary AML. Subclonal signaling gene mutations are common at MDS (often at low levels), show complex and convergent patterns of clonal evolution, and are associated with future progression to secondary AML. See related article by Guess et al., p. 316 (33). See related commentary by Romine and van Galen, p. 270. This article is highlighted in the In This Issue feature, p. 265.