Timothy J Ley

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 33

Top Topics

Acute Myeloid Leukemia

Dna Methylation

Metastatic Colorectal Cancer

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Science advances

JCO precision oncology

This page only lists publications with an associated author ORCID identifier.

Publications

Yang Li, Haley J Abel, Michelle Cai, Taylor A LaValle, Tiankai Yin, Nichole M Helton, Amanda M Smith, Christopher A Miller, Timothy J Ley
Rapid and accurate remethylation of DNA in Dnmt3a- deficient hematopoietic cells with restoration of DNMT3A activity. Science advances 10 (5) (2024)
Casey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Ziheng Xu, Nichole M Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Casey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Ziheng Xu, Nichole M Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Casey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Ziheng Xu, Nichole M Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Yang Li, Haley J Abel, Michelle Cai, Taylor A LaValle, Tiankai Yin, Nichole M Helton, Amanda M Smith, Christopher A Miller, Timothy J Ley
Rapid and accurate remethylation of DNA in Dnmt3a- deficient hematopoietic cells with restoration of DNMT3A activity. Science advances 10 (5) (2024)
Casey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Ziheng Xu, Nichole M Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Yang Li, Haley J Abel, Michelle Cai, Taylor A LaValle, Tiankai Yin, Nichole M Helton, Amanda M Smith, Christopher A Miller, Timothy J Ley
Rapid and accurate remethylation of DNA in Dnmt3a- deficient hematopoietic cells with restoration of DNMT3A activity. Science advances 10 (5) (2024)
Yang Li, Haley J Abel, Michelle Cai, Taylor A LaValle, Tiankai Yin, Nichole M Helton, Amanda M Smith, Christopher A Miller, Timothy J Ley
Rapid and accurate remethylation of DNA in Dnmt3a- deficient hematopoietic cells with restoration of DNMT3A activity. Science advances 10 (5) (2024)
Casey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Ziheng Xu, Nichole M Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Casey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Ziheng Xu, Nichole M Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Yang Li, Haley J Abel, Michelle Cai, Taylor A LaValle, Tiankai Yin, Nichole M Helton, Amanda M Smith, Christopher A Miller, Timothy J Ley
Rapid and accurate remethylation of DNA in Dnmt3a- deficient hematopoietic cells with restoration of DNMT3A activity. Science advances 10 (5) (2024)
Casey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Ziheng Xu, Nichole M Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Michael J Slade, Reza Ghasemi, Michelle O'Laughlin, Tasha Burton, Robert S Fulton, Haley J Abel, Eric J Duncavage, Timothy J Ley, Meagan A Jacoby, David H Spencer
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing. JCO precision oncology 7 (2023)
Michael J Slade, Reza Ghasemi, Michelle O'Laughlin, Tasha Burton, Robert S Fulton, Haley J Abel, Eric J Duncavage, Timothy J Ley, Meagan A Jacoby, David H Spencer
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing. JCO precision oncology 7 (2023)
Michael J Slade, Reza Ghasemi, Michelle O'Laughlin, Tasha Burton, Robert S Fulton, Haley J Abel, Eric J Duncavage, Timothy J Ley, Meagan A Jacoby, David H Spencer
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing. JCO precision oncology 7 (2023)
Michael J Slade, Reza Ghasemi, Michelle O'Laughlin, Tasha Burton, Robert S Fulton, Haley J Abel, Eric J Duncavage, Timothy J Ley, Meagan A Jacoby, David H Spencer
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing. JCO precision oncology 7 (2023)
Michael J Slade, Reza Ghasemi, Michelle O'Laughlin, Tasha Burton, Robert S Fulton, Haley J Abel, Eric J Duncavage, Timothy J Ley, Meagan A Jacoby, David H Spencer
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing. JCO precision oncology 7 (2023)
Michael H Kramer, Qiang Zhang, Robert W Sprung, Ryan B Day, Petra Erdmann-Gilmore, Yang Li, Ziheng Xu, Nichole M Helton, Daniel R George, Yiling Mi, Peter Westervelt, Jacqueline E Payton, Sai M Ramakrishnan, Christopher A Miller, Daniel C Link, John F DiPersio, Matthew J Walter, R Reid Townsend, Timothy J Ley
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia. Blood 140 (13) (2022)
Andrew J Menssen, Ajay Khanna, Christopher A Miller, Sridhar Nonavinkere Srivatsan, Gue Su Chang, Jin Shao, Joshua Robinson, Michele O'Laughlin, Catrina C Fronick, Robert S Fulton, Kimberly Brendel, Sharon E Heath, Raya Saba, John S S Welch, David H Spencer, Jacqueline E Payton, Peter Westervelt, John F DiPersio, Daniel C Link, Matthew J Schuelke, Meagan A Jacoby, Eric J Duncavage, Timothy J Ley, Matthew J Walter
Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression. Blood cancer discovery 3 (4) (2022)
Francesca Ferraro, Christopher A Miller, Keegan A Christensen, Nichole M Helton, Margaret O'Laughlin, Catrina C Fronick, Robert S Fulton, Jessica Kohlschmidt, Ann-Kathrin Eisfeld, Clara D Bloomfield, Sai Mukund Ramakrishnan, Ryan B Day, Lukas D Wartman, Geoffrey L Uy, John S Welch, Matthew J Christopher, Sharon E Heath, Jack D Baty, Matthew J Schuelke, Jacqueline E Payton, David H Spencer, Michael P Rettig, Daniel C Link, Matthew J Walter, Peter Westervelt, John F DiPersio, Timothy J Ley
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes. Proceedings of the National Academy of Sciences of the United States of America 118 (49) (2022)
Georgina L Ryland, Masayuki Umeda, Linda Holmfeldt, Sören Lehmann, Morten Krogh Krogh Herlin, Jing J Ma, Mahsa Khanlari, Jeffrey E Rubnitz, Rhonda E Ries, Hansen J Kosasih, Paul G Ekert, Hwee Ngee Goh, Ing Soo Tiong, Sean M Grimmond, Claudia Haferlach, Ryan B Day, Timothy J Ley, Soheil Meshinchi, Xiaotu Ma, Piers Blombery, Jeffery M Klco
Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions. Blood (2022)
Howard H Garrison, Timothy J Ley
Physician-scientists in the United States at 2020: Trends and concerns. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36 (5) (2022)
Sidan Li, Juo-Chin Yao, Karolyn A Oetjen, Joseph R Krambs, Jun Xia, Jingzhu Zhang, Amy P Schmidt, Nichole M Helton, Robert S Fulton, Sharon E Heath, Isaiah R Turnbull, Gabriel Mbalaviele, Timothy J Ley, Matthew J Walter, Daniel C Link
IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function. Blood 140 (14) (2022)
Margaret A Ferris, Amanda M Smith, Sharon E Heath, Eric J Duncavage, Matthew J Oberley, David R Freyer, Robert Wynn, Sofia Douzgou Houge, John M Maris, Anne F Reilly, Melinda Wu, Florence Choo, Roel B Fiets, Saskia Koene, David H Spencer, Christopher A Miller, Marwan S Shinawi, Timothy J Ley
DNMT3A Overgrowth Syndrome is associated with the development of hematopoietic malignancies in children and young adults. Blood (2021)
Ruiyang Liu, Qingsong Gao, Steven M Foltz, Jared S Fowles, Lijun Yao, Julia Tianjiao Wang, Song Cao, Hua Sun, Michael C Wendl, Sunantha Sethuraman, Amila Weerasinghe, Michael P Rettig, Erik P Storrs, Christopher J Yoon, Matthew A Wyczalkowski, Joshua F McMichael, Daniel R Kohnen, Justin King, Scott R Goldsmith, Julie O'Neal, Robert S Fulton, Catrina C Fronick, Timothy J Ley, Reyka G Jayasinghe, Mark A Fiala, Stephen T Oh, John F Dipersio, Ravi Vij, Li Ding
Co-evolution of tumor and immune cells during progression of multiple myeloma. Nature communications 12 (1) (2021)
David H Spencer, Molly C Schroeder, Michele O'Laughlin, Roxanne Wilson, Sandra MacMillan, Andrew Bohannon, Scott Kruchowski, John Garza, Feiyu Du, Andrew E O Hughes, Josh Robinson, Emma Hughes, Sharon E Heath, Jack D Baty, Julie Neidich, Matthew J Christopher, Meagan A Jacoby, Geoffrey L Uy, Robert S Fulton, Christopher A Miller, Jacqueline E Payton, Daniel C Link, Matthew J Walter, Peter Westervelt, John F DiPersio, Timothy J Ley, David H Spencer
Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers. The New England journal of medicine 384 (10) (2021)
Casey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Michelle A Cai, Timothy P Rooney, Nichole M Helton, Mieke Hoock, Sai Mukund Ramakrishnan, Sridhar Nonavinkere Srivatsan, Lukas D Wartman, Christopher A Miller, Timothy J Ley
Tumor suppressor function of Gata2 in acute promyelocytic leukemia. Blood 138 (13) (2021)
Amanda M Smith, Taylor A LaValle, Marwan S Shinawi, Sai M Ramakrishnan, Haley J Abel, Cheryl A Hill, Nicole M Kirkland, Michael P Rettig, Nichole M Helton, Sharon E Heath, Francesca Ferraro, David Y Chen, Sangeeta Adak, Clay F Semenkovich, Diana L Christian, Jenna R Martin, Harrison W Gabel, Christopher A Miller, Timothy J Ley
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome. Nature communications 12 (1) (2021)
Elisabeth R Wilson, Nichole M Helton, Sharon E Heath, Robert S Fulton, Jacqueline E Payton, John S Welch, Matthew J Walter, Peter Westervelt, John F Dipersio, Daniel C Link, Christopher A Miller, Timothy J Ley, David H Spencer
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells. Leukemia (2021)
David Y Chen, Ian M Ferguson, Krista A Braun, Leslie A Sutton, Nichole M Helton, Sai Mukund Ramakrishnan, Amanda M Smith, Christopher A Miller, Timothy J Ley
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype. Proceedings of the National Academy of Sciences of the United States of America 118 (16) (2021)
Shamika Ketkar, Angela M Verdoni, Amanda M Smith, Celia V Bangert, Elizabeth R Leight, David Y Chen, Meryl K Brune, Nichole M Helton, Mieke Hoock, Daniel R George, Catrina Fronick, Robert S Fulton, Sai Mukund Ramakrishnan, Gue Su Chang, Allegra A Petti, David H Spencer, Christopher A Miller, Timothy J Ley
Remethylation of Dnmt3a -/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing. Proceedings of the National Academy of Sciences of the United States of America 117 (6) (2020)
Ha X Dang, Bradley Aaron Krasnick, Brian S White, Julie G Grossman, Matthew S Strand, Jin Zhang, Christopher R Cabanski, Christopher A Miller, Robert S Fulton, S Peter Goedegebuure, Catrina C Fronick, Malachi Griffith, David E Larson, Brian D Goetz, Jason R Walker, William G Hawkins, Steven M Strasberg, David C Linehan, Kian-Huat Lim, A Craig Lockhart, Elaine R Mardis, Richard K Wilson, Timothy J Ley, Christopher A Maher, Ryan C Fields
The clonal evolution of metastatic colorectal cancer. Science advances 6 (24) (2020)
Jessica M Silva-Fisher, Ha X Dang, Nicole M White, Matthew S Strand, Bradley A Krasnick, Emily B Rozycki, Gejae G L Jeffers, Julie G Grossman, Maureen K Highkin, Cynthia Y Tang, Christopher R Cabanski, Abdallah Eteleeb, Jacqueline Mudd, S Peter Goedegebuure, Jingqin Luo, Elaine R Mardis, Richard K Wilson, Timothy J Ley, Albert C Lockhart, Ryan C Fields, Christopher A Maher
Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression. Nature communications 11 (1) (2020)