Neoantigen Cancer Vaccines and Different Immune Checkpoint Therapies Each Utilize Both Converging and Distinct Mechanisms that in Combination Enable Synergistic Therapeutic Efficacy.
Sunita KeshariAlexander S ShavkunovQi MiaoAkata SahaCharmelle D WilliamsAnna M HighsmithJosué E PinedaElise AlspachKenneth H HuKristen E PaukenKen ChenMatthew M GubinPublished in: bioRxiv : the preprint server for biology (2024)
stem-like and proliferating NeoAg-specific CD8 T cells CD8 TCR clonotype expansion relates to phenotype and functional state associated with immunotherapyNeoAg vaccines induce partially distinct macrophage remodeling from ICTNeoAg vaccines synergize with ICT, exceeding combination αCTLA-4/αPD-1 ICT efficacy.