Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil.
Ricardo Arraes de Alencar XimenesDemócrito de Barros Miranda FilhoUlísses Ramos MontarroyosCelina Maria Turchi MartelliThalia Velho Barreto de AraújoElizabeth Bailey BrickleyMaria de Fátima Pessoa Militão de AlbuquerqueWayner Vieira SouzaLiana O VenturaCamila V VenturaAdriana L GoisMariana C LealDanielle Maria da Silva OliveiraSophie Helena EickmannMaria Durce C G CarvalhoPaula Fabiana Sobral da SilvaMaria Angela Wanderley RochaRegina Coeli Ferreira RamosSinval Pinto Brandão FilhoMarli Tenorio CordeiroLuciana Caroline Albuquerque BezerraGeorge DimechSandra Valongueiro AlvesPedro Pires Ferreira NetoPriscila Mayrelle da Silva CastanhaRafael DhaliaErnesto Torres de Azevedo MarquesLaura C Rodriguesnull nullPublished in: PLoS neglected tropical diseases (2021)
376 women had confirmed and suspected exposure to ZIKV. Among evaluable children born to these mothers, 20% presented with an adverse outcome compatible with exposure to ZIKV during pregnancy. The absolute risk of microcephaly was 2.9% (11/376), of calcifications and/or ventriculomegaly was 7.2% (13/180), of additional neurologic alterations was 5.3% (13/245), of ophthalmologic abnormalities was 7% (15/214), and of dysphagia was 1.8% (4/226). Less than 1% of the children experienced abnormalities across all of the domains simultaneously. Interpretation: Although approximately one-fifth of children with confirmed and suspected exposure to ZIKV in pregnancy presented with at least one abnormality compatible with CZS, the manifestations presented more frequently in isolation than in combination. Due to the rare nature of some outcomes and the possibility of later manifestations, large scale individual participant data meta-analysis and the long-term evaluation of children are imperative to identify the full spectrum of this syndrome and to plan actions to reduce damages.