Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment.
Matthew SnelsonDevy DeliyantiSih Min TanAnna M DrakeCassandra de PasqualeVinod KumarTrent M WoodruffJennifer L Wilkinson-BerkaMelinda T CoughlanPublished in: Nutrition & diabetes (2024)
Resistant starch supplementation in diabetes promotes beneficial circulating microbially-derived metabolites and improves intestinal permeability, accompanied by a modulation in the inflammatory profile of the kidney including neutrophil infiltration, complement activation, and albuminuria. These findings indicate that resistant starch can regulate immune and inflammatory responses in the kidney and support the therapeutic potential of resistant starch supplementation in diabetes on kidney health.