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EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer transformation.

Ying LiYongwen LiHongbing ZhangRuifeng ShiZihe ZhangHongyu LiuJun Chen
Published in: BMC pulmonary medicine (2021)
Our data suggest that the aberrant expression of EML4-ALK leads to JAK2-STAT signaling pathway activation, which is essential for the development of non-small cell lung cancer.
Keyphrases
  • signaling pathway
  • advanced non small cell lung cancer
  • poor prognosis
  • pi k akt
  • epithelial mesenchymal transition
  • big data
  • oxidative stress
  • machine learning
  • long non coding rna
  • deep learning