EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer transformation.
Ying LiYongwen LiHongbing ZhangRuifeng ShiZihe ZhangHongyu LiuJun ChenPublished in: BMC pulmonary medicine (2021)
Our data suggest that the aberrant expression of EML4-ALK leads to JAK2-STAT signaling pathway activation, which is essential for the development of non-small cell lung cancer.