Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.

Shifeng LingTienan ChenShaojiao WangWei ZhangRujiang ZhouXuechun XiaZhengju YaoYing FanSong NingJiayin LiuLianju QinHaley O TuckerNiansong WangXizhi Guo

Published in: Stem cell research & therapy (2023)

These findings reveal a heretofore unanticipated mechanism by which deacetylation of FOXP1 potentiates self-renewal of MSC and protects them from cellular senescence. Acetylation of FOXP1 residue T172 as a critical modification underlying MSC proliferative capacity. We suggest that in vivo gene editing of FOXP1 may provide a novel avenue for manipulating MSC capability during large-scale expansion in clinical trials.

Keyphrases

regulatory t cells
mesenchymal stem cells
clinical trial
dendritic cells
histone deacetylase
bone marrow
genome wide
endothelial cells
gene expression
single cell
randomized controlled trial
immune response
amino acid
study protocol
phase ii