A Study on the Planarian Model Confirms the Antioxidant Properties of Tameron against X-ray- and Menadione-Induced Oxidative Stress.
Elena TsarkovaKristina FilippovaVera AfanasyevaOlga ErmakovaAnastasia KolotovaArtem BlagodatskiArtem M ErmakovPublished in: Antioxidants (Basel, Switzerland) (2023)
Ionizing radiation and radiation-related oxidative stress are two important factors responsible for the death of actively proliferating cells, thus drastically reducing the regeneration capacity of living organisms. Planarian flatworms are freshwater invertebrates that are rich in stem cells called neoblasts and, therefore, present a well-established model for studies on regeneration and the testing of novel antioxidant and radioprotective substances. In this work, we tested an antiviral and antioxidant drug Tameron (Monosodium α-Luminol or 5-amino-2,3-dihydro-1,4-phthalazinedione sodium salt) for its ability to reduce the harm of X-ray- and chemically induced oxidative stress on a planarian model. Our study has revealed the ability of Tameron to effectively protect planarians from oxidative stress while enhancing their regenerative capacity by modulating the expression of neoblast marker genes and NRF-2-controlled oxidative stress response genes.
Keyphrases
- oxidative stress
- stem cells
- induced apoptosis
- diabetic rats
- dna damage
- ischemia reperfusion injury
- high resolution
- anti inflammatory
- poor prognosis
- genome wide
- signaling pathway
- magnetic resonance imaging
- hydrogen peroxide
- cell therapy
- single cell
- cell cycle arrest
- bioinformatics analysis
- nitric oxide
- endoplasmic reticulum stress
- mesenchymal stem cells
- drug induced
- magnetic resonance
- radiation therapy
- dna methylation
- electron microscopy
- gram negative
- case control