5,6-dehydrokawain from the rhizome of Alpinia mutica Roxb. induced proangiogenic tumour-derived VEGF of HT-29 colorectal cancer.

Ibrahim MalamiAliyu MuhammadIbrahim B AbubakarImaobong C EttiPeter M WaziriRamadan M AbubakarHalilu E Mshelia

Published in: Natural product research (2017)

Vascular endothelial growth factor (VEGF) is a glycoprotein vital to the regulation of vascular endothelial cells proliferation, migration and angiogenesis. The expression of VEGF is required for the formation of new blood vessels critical in supplying oxygen and nutrition in the course of tumorigenesis. The present study investigated the effect of 5,6-dehydrokawain isolated from the rhizomes of Alpinia mutica on VEGF expression in vitro using HT-29 cell line. The results revealed that 5,6-dehydrokawain induced the expression of proangiogenic tumour-derived VEGF of HT-29 cells, which may explain the inability of 5,6-dehydrokawain in suppressing cancer cells proliferation.

Keyphrases

vascular endothelial growth factor
endothelial cells
high glucose
poor prognosis
signaling pathway
induced apoptosis
diabetic rats
binding protein
physical activity
oxidative stress
long non coding rna
cell cycle arrest
atomic force microscopy
high resolution
pi k akt
endoplasmic reticulum stress