Clinical Efficacy and Whole-Exome Sequencing of Liquid Biopsies in a Phase IB/II Study of Bazedoxifene and Palbociclib in Advanced Hormone Receptor-Positive Breast Cancer.
Junko TsujiTianyu LiAlbert GrinshpunTim H H CoorensDouglas RussoLeilani AndersonRebecca ReesAgostina NardoneCandace PattersonNiall J LennonCarrie CibulskisIgnaty LeshchinerNabihah TayobSara M TolaneyNadine M TungDonald P McDonnellIan E KropEric P WinerChip StewartGad A GetzRinath M JeselsohnPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
The combination of palbociclib and bazedoxifene has clinical efficacy and an acceptable safety profile in a heavily pretreated patient population with advanced HR+/HER2- breast cancer. These results merit continued investigation of bazedoxifene in breast cancer.