Ignaty Leshchiner (I Leshchiner)

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 25

Top Topics

Chronic Lymphocytic Leukemia

Hematopoietic Stem Cell

Mitochondrial Dna

Top Venues

Nature medicine

Nature communications

Nature biotechnology

This page only lists publications with an associated author ORCID identifier.

Publications

Livius Penter, Nicoletta Cieri, Katie Maurer, Marwan Kwok, Haoxiang Lyu, Wesley S Lu, Giacomo Oliveira, Satyen H Gohil, Ignaty Leshchiner, Caleb A Lareau, Leif S Ludwig, Donna S Neuberg, Haesook T Kim, Shuqiang Li, Lars Bullinger, Jerome Ritz, Gad A Getz, Jacqueline S Garcia, Robert J Soiffer, Kenneth J Livak, Catherine J Wu
Tracking rare single donor and recipient immune and leukemia cells after allogeneic hematopoietic cell transplantation using mitochondrial DNA mutations. Blood cancer discovery (2024)
Adriana Salcedo, Maxime Tarabichi, Alex Buchanan, Shadrielle M G Espiritu, Hongjiu Zhang, Kaiyi Zhu, Tai-Hsien Ou Yang, Ignaty Leshchiner, Dimitris Anastassiou, Yuanfang Guan, Gun Ho Jang, Mohammed Faizal Eeman Mootor, Kerstin Haase, Amit G Deshwar, William Zou, Imaad Umar, Stefan Dentro, Jeff A Wintersinger, Kami Chiotti, Jonas Demeulemeester, Clemency Jolly, Lesia Sycza, Minjeong Ko, null null, null null, David C Wedge, Quaid D Morris, Kyle Ellrott, Peter Van Loo, Paul C Boutros
Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction. Nature biotechnology (2024)
Adriana Salcedo, Maxime Tarabichi, Alex Buchanan, Shadrielle M G Espiritu, Hongjiu Zhang, Kaiyi Zhu, Tai-Hsien Ou Yang, Ignaty Leshchiner, Dimitris Anastassiou, Yuanfang Guan, Gun Ho Jang, Mohammed Faizal Eeman Mootor, Kerstin Haase, Amit G Deshwar, William Zou, Imaad Umar, Stefan Dentro, Jeff A Wintersinger, Kami Chiotti, Jonas Demeulemeester, Clemency Jolly, Lesia Sycza, Minjeong Ko, null null, null null, David C Wedge, Quaid D Morris, Kyle Ellrott, Peter Van Loo, Paul C Boutros
Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction. Nature biotechnology (2024)
Ignaty Leshchiner, Edmund A Mroz, Justin Cha, Daniel Rosebrock, Oliver Spiro, Juliana Bonilla-Velez, William C Faquin Md PhD, Armida Lefranc-Torres, Derrick T Lin, William A Michaud, Gad A Getz, James W Rocco
Inferring early genetic progression in cancers with unobtainable premalignant disease. Nature cancer 4 (4) (2023)
Erin M Parry, Ignaty Leshchiner, Romain Guieze, Connor Johnson, Eugen Tausch, Sameer A Parikh, Camilla K Lemvigh, Julien Broseus, Sebastien Hergalant, Conor Messer, Filippo Utro, Chaya Levovitz, Kahn Rhrissorrakrai, Liang Li, Daniel Rosebrock, Shanye Yin, Stephanie L Deng, Kara Slowik, Raquel Jacobs, Teddy Huang, Shuqiang Li, Geoffrey G Fell, Robert A Redd, Ziao Lin, Binyamin Asher Knisbacher, Dimitri Livitz, Christof Schneider, Neil Ruthen, Liudmila Elagina, Amaro Taylor-Weiner, Bria Persaud, Aina Z Martinez, Stacey M Fernandes, Noelia Purroy, Annabelle J Anandappa, Jialin Ma, Julian M Hess, Laura Z Rassenti, Thomas J Kipps, Nitin Jain, William G Wierda, Florence Cymbalista, Pierre Feugier, Neil E Kay, Kenneth J Livak, Brian P Danysh, Chip Stewart, Donna S Neuberg, Matthew S Davids, Jennifer R Brown, Laxmi Parida, Stephan Stilgenbauer, Gad A Getz, Catherine J Wu
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nature medicine 29 (1) (2023)
Ignaty Leshchiner, Edmund A Mroz, Justin Cha, Daniel Rosebrock, Oliver Spiro, Juliana Bonilla-Velez, William C Faquin Md PhD, Armida Lefranc-Torres, Derrick T Lin, William A Michaud, Gad A Getz, James W Rocco
Inferring early genetic progression in cancers with unobtainable premalignant disease. Nature cancer 4 (4) (2023)
Erin M Parry, Ignaty Leshchiner, Romain Guieze, Connor Johnson, Eugen Tausch, Sameer A Parikh, Camilla K Lemvigh, Julien Broseus, Sebastien Hergalant, Conor Messer, Filippo Utro, Chaya Levovitz, Kahn Rhrissorrakrai, Liang Li, Daniel Rosebrock, Shanye Yin, Stephanie L Deng, Kara Slowik, Raquel Jacobs, Teddy Huang, Shuqiang Li, Geoffrey G Fell, Robert A Redd, Ziao Lin, Binyamin Asher Knisbacher, Dimitri Livitz, Christof Schneider, Neil Ruthen, Liudmila Elagina, Amaro Taylor-Weiner, Bria Persaud, Aina Z Martinez, Stacey M Fernandes, Noelia Purroy, Annabelle J Anandappa, Jialin Ma, Julian M Hess, Laura Z Rassenti, Thomas J Kipps, Nitin Jain, William G Wierda, Florence Cymbalista, Pierre Feugier, Neil E Kay, Kenneth J Livak, Brian P Danysh, Chip Stewart, Donna S Neuberg, Matthew S Davids, Jennifer R Brown, Laxmi Parida, Stephan Stilgenbauer, Gad A Getz, Catherine J Wu
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nature medicine 29 (1) (2023)
Ignaty Leshchiner, Edmund A Mroz, Justin Cha, Daniel Rosebrock, Oliver Spiro, Juliana Bonilla-Velez, William C Faquin Md PhD, Armida Lefranc-Torres, Derrick T Lin, William A Michaud, Gad A Getz, James W Rocco
Inferring early genetic progression in cancers with unobtainable premalignant disease. Nature cancer 4 (4) (2023)
Erin M Parry, Ignaty Leshchiner, Romain Guieze, Connor Johnson, Eugen Tausch, Sameer A Parikh, Camilla K Lemvigh, Julien Broseus, Sebastien Hergalant, Conor Messer, Filippo Utro, Chaya Levovitz, Kahn Rhrissorrakrai, Liang Li, Daniel Rosebrock, Shanye Yin, Stephanie L Deng, Kara Slowik, Raquel Jacobs, Teddy Huang, Shuqiang Li, Geoffrey G Fell, Robert A Redd, Ziao Lin, Binyamin Asher Knisbacher, Dimitri Livitz, Christof Schneider, Neil Ruthen, Liudmila Elagina, Amaro Taylor-Weiner, Bria Persaud, Aina Z Martinez, Stacey M Fernandes, Noelia Purroy, Annabelle J Anandappa, Jialin Ma, Julian M Hess, Laura Z Rassenti, Thomas J Kipps, Nitin Jain, William G Wierda, Florence Cymbalista, Pierre Feugier, Neil E Kay, Kenneth J Livak, Brian P Danysh, Chip Stewart, Donna S Neuberg, Matthew S Davids, Jennifer R Brown, Laxmi Parida, Stephan Stilgenbauer, Gad A Getz, Catherine J Wu
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nature medicine (2023)
Erin M Parry, Ignaty Leshchiner, Romain Guieze, Connor Johnson, Eugen Tausch, Sameer A Parikh, Camilla K Lemvigh, Julien Broseus, Sebastien Hergalant, Conor Messer, Filippo Utro, Chaya Levovitz, Kahn Rhrissorrakrai, Liang Li, Daniel Rosebrock, Shanye Yin, Stephanie L Deng, Kara Slowik, Raquel Jacobs, Teddy Huang, Shuqiang Li, Geoffrey G Fell, Robert A Redd, Ziao Lin, Binyamin Asher Knisbacher, Dimitri Livitz, Christof Schneider, Neil Ruthen, Liudmila Elagina, Amaro Taylor-Weiner, Bria Persaud, Aina Z Martinez, Stacey M Fernandes, Noelia Purroy, Annabelle J Anandappa, Jialin Ma, Julian M Hess, Laura Z Rassenti, Thomas J Kipps, Nitin Jain, William G Wierda, Florence Cymbalista, Pierre Feugier, Neil E Kay, Kenneth J Livak, Brian P Danysh, Chip Stewart, Donna S Neuberg, Matthew S Davids, Jennifer R Brown, Laxmi Parida, Stephan Stilgenbauer, Gad A Getz, Catherine J Wu
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nature medicine 29 (1) (2023)
Erin M Parry, Ignaty Leshchiner, Romain Guieze, Connor Johnson, Eugen Tausch, Sameer A Parikh, Camilla K Lemvigh, Julien Broseus, Sebastien Hergalant, Conor Messer, Filippo Utro, Chaya Levovitz, Kahn Rhrissorrakrai, Liang Li, Daniel Rosebrock, Shanye Yin, Stephanie L Deng, Kara Slowik, Raquel Jacobs, Teddy Huang, Shuqiang Li, Geoffrey G Fell, Robert A Redd, Ziao Lin, Binyamin Asher Knisbacher, Dimitri Livitz, Christof Schneider, Neil Ruthen, Liudmila Elagina, Amaro Taylor-Weiner, Bria Persaud, Aina Z Martinez, Stacey M Fernandes, Noelia Purroy, Annabelle J Anandappa, Jialin Ma, Julian M Hess, Laura Z Rassenti, Thomas J Kipps, Nitin Jain, William G Wierda, Florence Cymbalista, Pierre Feugier, Neil E Kay, Kenneth J Livak, Brian P Danysh, Chip Stewart, Donna S Neuberg, Matthew S Davids, Jennifer R Brown, Laxmi Parida, Stephan Stilgenbauer, Gad A Getz, Catherine J Wu
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nature medicine 29 (1) (2023)
Andreas Varkaris, Ferran Fece de la Cruz, Elizabeth E Martin, Bryanna L Norden, Nicholas Chevalier, Allison M Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P Danysh, Laxmi Parida, Ioannis Sanidas, Yongli Ji, Kayao Lau, Gerburg M Wulf, Aditya Bardia, Laura M Spring, Steven Jay Isakoff, Jochen K Lennerz, Levi Pierce, Ermira Pazolli, Gad A Getz, Ryan B Corcoran, Dejan Juric
Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations. Cancer discovery (2023)
Ignaty Leshchiner, Edmund A Mroz, Justin Cha, Daniel Rosebrock, Oliver Spiro, Juliana Bonilla-Velez, William C Faquin Md PhD, Armida Lefranc-Torres, Derrick T Lin, William A Michaud, Gad A Getz, James W Rocco
Inferring early genetic progression in cancers with unobtainable premalignant disease. Nature cancer 4 (4) (2023)
Arvind Ravi, Matthew D Hellmann, Monica B Arniella, Mark Holton, Samuel S Freeman, Vivek Naranbhai, Chip Stewart, Ignaty Leshchiner, Jaegil Kim, Yo Akiyama, Aaron T Griffin, Natalie I Vokes, Mustafa Sakhi, Vashine Kamesan, Hira Rizvi, Biagio Ricciuti, Patrick M Forde, Valsamo Anagnostou, Jonathan W Riess, Don L Gibbons, Nathan A Pennell, Vamsidhar Velcheti, Subba R Digumarthy, Mari A Mino-Kenudson, Andrea Califano, John Victor Heymach, Roy S Herbst, Julie R Brahmer, Kurt A Schalper, Victor E Velculescu, Brian S Henick, Naiyer Rizvi, Pasi A Janne, Mark M Awad, Andrew Chow, Benjamin D Greenbaum, Marta Luksza, Alice T Shaw, Jedd D Wolchok, Nir Hacohen, Gad A Getz, Justin F Gainor
Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer. Nature genetics (2023)
Ignaty Leshchiner, Edmund A Mroz, Justin Cha, Daniel Rosebrock, Oliver Spiro, Juliana Bonilla-Velez, William C Faquin Md PhD, Armida Lefranc-Torres, Derrick T Lin, William A Michaud, Gad A Getz, James W Rocco
Inferring early genetic progression in cancers with unobtainable premalignant disease. Nature cancer 4 (4) (2023)
Ignaty Leshchiner, Edmund A Mroz, Justin Cha, Daniel Rosebrock, Oliver Spiro, Juliana Bonilla-Velez, William C Faquin Md PhD, Armida Lefranc-Torres, Derrick T Lin, William A Michaud, Gad A Getz, James W Rocco
Inferring early genetic progression in cancers with unobtainable premalignant disease. Nature cancer 4 (4) (2023)
Ignaty Leshchiner, Edmund A Mroz, Justin Cha, Daniel Rosebrock, Oliver Spiro, Juliana Bonilla-Velez, William C Faquin Md PhD, Armida Lefranc-Torres, Derrick T Lin, William A Michaud, Gad A Getz, James W Rocco
Inferring early genetic progression in cancers with unobtainable premalignant disease. Nature cancer (2023)
Junko Tsuji, Tianyu Li, Albert Grinshpun, Tim H H Coorens, Douglas Russo, Leilani Anderson, Rebecca Rees, Agostina Nardone, Candace Patterson, Niall J Lennon, Carrie Cibulskis, Ignaty Leshchiner, Nabihah Tayob, Sara M Tolaney, Nadine M Tung, Donald P McDonnell, Ian E Krop, Eric P Winer, Chip Stewart, Gad A Getz, Rinath M Jeselsohn
Clinical Efficacy and Whole-Exome Sequencing of Liquid Biopsies in a Phase IB/II Study of Bazedoxifene and Palbociclib in Advanced Hormone Receptor-Positive Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (23) (2022)
Aparna R Parikh, Ignaty Leshchiner, Liudmila Elagina, Lipika Goyal, Chaya Levovitz, Giulia Siravegna, Dimitri Livitz, Kahn Rhrissorrakrai, Elizabeth E Martin, Emily E Van Seventer, Megan Hanna, Kara Slowik, Filippo Utro, Christopher J Pinto, Alicia Wong, Brian P Danysh, Ferran Fece de la Cruz, Isobel J Fetter, Brandon A Nadres, Heather A Shahzade, Jill N Allen, Lawrence S Blaszkowsky, Jeffrey W Clark, Bruce Giantonio, Janet E Murphy, Ryan D Nipp, Eric Roeland, David P Ryan, Colin D Weekes, Eunice L Kwak, Jason E Faris, Jennifer Y Wo, François Aguet, Ipsita Dey-Guha, Mehlika Hazar-Rethinam, Dora Dias-Santagata, David Tsai Ting, Andrew X Zhu, Theodore S Hong, Todd R Golub, A John Iafrate, Viktor A Adalsteinsson, Alberto Bardelli, Laxmi Parida, Dejan Juric, Gad A Getz, Ryan B Corcoran
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nature medicine 25 (9) (2019)
N J Haradhvala, J Kim, Y E Maruvka, Paz Polak, D Rosebrock, Dimitri Livitz, J M Hess, Ignaty Leshchiner, A Kamburov, K W Mouw, M S Lawrence, Gad A Getz
Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair. Nature communications 9 (1) (2018)
Bjoern Chapuy, Chip Stewart, Andrew J Dunford, Jaegil Kim, Atanas Kamburov, Robert A Redd, Mike S Lawrence, Margaretha G M Roemer, Amy J Li, Marita Ziepert, Annette M Staiger, Jeremiah A Wala, Matthew D Ducar, Ignaty Leshchiner, Ester Rheinbay, Amaro Taylor-Weiner, Caroline A Coughlin, Julian M Hess, Chandra S Pedamallu, Dimitri Livitz, Daniel Rosebrock, Mara Rosenberg, Adam A Tracy, Heike Horn, Paul van Hummelen, Andrew L Feldman, Brian K Link, Anne J Novak, James R Cerhan, Thomas M Habermann, Reiner Siebert, Andreas Rosenwald, Aaron R Thorner, Matthew L Meyerson, Todd R Golub, Rameen Beroukhim, Gerald G Wulf, German Ott, Scott J Rodig, Stefano Monti, Donna S Neuberg, Markus Loeffler, Michael Pfreundschuh, Lorenz Trümper, Gad A Getz, Margaret A Shipp
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nature medicine 24 (5) (2018)
Chip Stewart, Ignaty Leshchiner, Julian M Hess, Gad A Getz
Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification". Science (New York, N.Y.) 361 (6409) (2018)
Priscilla K Brastianos, Naema Nayyar, Daniel Rosebrock, Ignaty Leshchiner, Corey M Gill, Dimitri Livitz, Mia S Bertalan, Megan D'Andrea, Kaitlin Hoang, Elisa Aquilanti, Ugonma N Chukwueke, Andrew Kaneb, Andrew Chi, Scott Plotkin, Elizabeth R Gerstner, Mathew P Frosch, Mario L Suvà, Daniel P Cahill, Gad A Getz, Tracy T Batchelor
Resolving the phylogenetic origin of glioblastoma via multifocal genomic analysis of pre-treatment and treatment-resistant autopsy specimens. NPJ precision oncology 1 (1) (2017)
Viktor A Adalsteinsson, Gavin Ha, Samuel S Freeman, Atish D Choudhury, Daniel G Stover, Heather A Parsons, Gregory Gydush, Sarah C Reed, Denisse Rotem, Justin Rhoades, Denis Loginov, Dimitri Livitz, Daniel Rosebrock, Ignaty Leshchiner, Jaegil Kim, Chip Stewart, Mara Rosenberg, Joshua M Francis, Cheng-Zhong Zhang, Ofir Cohen, Coyin Oh, Huiming Ding, Paz Polak, Max Lloyd, Sairah Mahmud, Karla Helvie, Margaret S Merrill, Rebecca A Santiago, Edward P O'Connor, Seong H Jeong, Rachel Leeson, Rachel M Barry, Joseph F Kramkowski, Zhenwei Zhang, Laura Polacek, Jens G Lohr, Molly Schleicher, Emily Lipscomb, Andrea Saltzman, Nelly M Oliver, Lori Marini, Adrienne G Waks, Lauren C Harshman, Sara M Tolaney, Eliezer M Van Allen, Eric P Winer, Nancy U Lin, Mari Nakabayashi, Mary-Ellen Taplin, Cory M Johannessen, Levi A Garraway, Todd R Golub, Jesse S Boehm, Nikhil Wagle, Gad A Getz, J Christopher Love, Matthew L Meyerson
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. Nature communications 8 (1) (2017)
Dan A Landau, Clare Sun, Daniel Rosebrock, Sarah E M Herman, Joshua Fein, Mariela Sivina, Chingiz Underbayev, Delong Liu, Julia Hoellenriegel, Sarangan Ravichandran, Mohammed Z H Farooqui, Wandi Zhang, Carrie Cibulskis, Asaf Zviran, Donna S Neuberg, Dimitri Livitz, Ivana Bozic, Ignaty Leshchiner, Gad A Getz, Jan A Burger, Adrian Wiestner, Catherine J Wu
The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy. Nature communications 8 (1) (2017)
Sek Won Kong, In-Hee Lee, Ignaty Leshchiner, Joel Krier, Peter Kraft, Heidi L Rehm, Robert C Green, Isaac S Kohane, Calum A MacRae, null null
Summarizing polygenic risks for complex diseases in a clinical whole-genome report. Genetics in medicine : official journal of the American College of Medical Genetics 17 (7) (2014)