Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis.

Chenran WangMichael A HaasSyn Kok YeoRitama PaulFuchun YangSubrahmanya VallabhapurapuXiaoyang QiDavid R PlasJun-Lin Guan

Published in: British journal of cancer (2021)

This study established an autophagy/lipid degradation/FAO/ATP generation pathway, which might be used in brain cancer cells under energy stresses to maintain high mTORC1 signalling for tumour progression.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
public health
fatty acid
resting state
multiple sclerosis
functional connectivity