Bacterial oncotraits rather than spatial organization are associated with dysplasia in ulcerative colitis.
Carlijn E BruggelingMaarten Te GroenDaniel R GarzaFamke van Heeckeren Tot OverlaerJoyce P M KrekelsBasma-Chick SulaimanDavy KarelAthreyu RulofAnne R SchaaphokDaniel L A H HornikxIris D NagtegaalBas E DutilhFrank HoentjenAnnemarie BoleijPublished in: Journal of Crohn's & colitis (2023)
Biofilms are a hallmark of UC, however, because of their high prevalence a poor biomarker for dysplasia. In contrast, colibactin presence and FadA absence independently associate with dysplasia in UC and might therefore be valuable biomarkers for future risk stratification and intervention strategies.