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Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer.

Carmine De AngelisXiaoyong FuMaria Letizia CataldoAgostina NardoneResel PereiraJamunarani VeeraraghavanSarmistha NandaLanfang QinVidyalakshmi SethunathNicholas WangSusan G HilsenbeckMatteo BenelliIlenia MigliaccioCristina GuarducciLuca MalorniLacey M LitchfieldJiangang LiuJoshua DonaldsonPier SelenicaDavid N BrownBritta WeigeltJorge S Reis-FilhoBen H ParkSara A HurvitzDennis J SlamonMothaffar F RimawiValerie M JansenRinath M JeselsohnC Kent OsborneRachel Schiff
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Aberrant IFN signaling is associated with intrinsic resistance to CDK4/6i. Experimentally, acquired resistance to palbociclib is associated with activation of the IFN pathway, warranting additional studies to clarify its involvement in resistance to CDK4/6i.
Keyphrases
  • positive breast cancer
  • signaling pathway
  • cell cycle
  • immune response
  • dendritic cells
  • oxidative stress
  • cell proliferation
  • breast cancer cells