DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease.
Marleen E JacobsJuliëtte N PouwMichel A Olde NordkampTimothy R D J RadstakeEmmerik F A LeijtenMarianne BoesPublished in: Immunotherapy advances (2020)
CD155 is increased on pro-inflammatory APCs, while the receptors DNAM1 and TIGIT expressed on T cells balance the inflammatory response by T cells. In psoriatic disease, low TIGIT expression on T cells is associated with systemic inflammation.