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DNA hypermethylation of PTPN22 gene promoter in children and adolescents with Hashimoto thyroiditis.

I KyrgiosS GizaA FragouG TzimagiorgisAssimina Galli-Tsinopoulou
Published in: Journal of endocrinological investigation (2020)
This study demonstrates for the first time that a relationship between autoimmune thyroiditis and PTPN22 gene promoter DNA methylation state is present, thus proposing another possible etiological association between thyroiditis and abnormalities of PTPN22 function. Further expression studies are required to confirm these findings.
Keyphrases
  • dna methylation
  • genome wide
  • copy number
  • gene expression
  • transcription factor
  • poor prognosis
  • genome wide identification
  • multiple sclerosis
  • single molecule
  • long non coding rna