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Plasma Metabolomic and Lipidomic Profiling of a Genetically Modified Mouse Model of Scavenger Receptor Class B Type I.

Jia LiuMingming ZhaoYizhang ZhuLemin ZhengYuxin Yin
Published in: Proteomics (2020)
Atherosclerosis is a chronic inflammatory disease of the arterial wall and is becoming the principal cause of death globally. The reverse cholesterol transport (RCT) mediated by scavenger receptor class B type I (SR-BI) is a major protection mechanism against atherosclerosis. To investigate the metabolome changes and to find potential biomarkers involved in RCT, nontargeted metabolomics and nontargeted lipidomics are applied to SR-BI knockout mice that are fed a high fat and high cholesterol diet. SR-BI knockout mice and controls are told apart using multidimensional statistical analysis, and potential biomarkers are found and identified. The pathophysiological meaning of the biomarkers and the perturbed metabolic pathways are also addressed, which could provide new evidence for atherosclerosis studies.
Keyphrases
  • cardiovascular disease
  • mouse model
  • low density lipoprotein
  • mass spectrometry
  • physical activity
  • oxidative stress
  • single cell
  • high resolution
  • advanced cancer
  • drug induced
  • psychometric properties