The opioid tramadol blocks the cardiac sodium channel Nav1.5 in HEK293 cells.
Lixia JiaMarieke W VeldkampArjan C HouwelingHanno L TanPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
Tramadol reduces Nav1.5 currents, in particular, at close-to-physiological membrane potentials. Fentanyl and codeine have no effects on Nav1.5 current.