Arjan C Houweling (Arie O Verkerk, A O Verkerk)

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 46

Top Topics

Atrial Fibrillation

Hypertrophic Cardiomyopathy

Direct Oral Anticoagulants

Top Venues

International journal of molecular sciences

Cardiovascular research

This page only lists publications with an associated author ORCID identifier.

Publications

Paul J M Wijnker, Rafeeh Dinani, Nico C van der Laan, Sila Algül, Bjorn C Knollmann, Arjan C Houweling, Carol Ann Remme, Coert J Zuurbier, Diederik W D Kuster, Jolanda van der Velden
Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors. Cardiovascular research 120 (3) (2024)
Paul J M Wijnker, Rafeeh Dinani, Nico C van der Laan, Sila Algül, Bjorn C Knollmann, Arjan C Houweling, Carol Ann Remme, Coert J Zuurbier, Diederik W D Kuster, Jolanda van der Velden
Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by SGLT2 inhibitors. Cardiovascular research (2024)
Giovanna Nasilli, Arjan C Houweling, Molly O'Reilly, Loukia Yiangou, Richard P Davis, Simona Casini, Carol Ann Remme
Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Biomedicines 12 (6) (2024)
Paul J M Wijnker, Rafeeh Dinani, Nico C van der Laan, Sila Algül, Bjorn C Knollmann, Arjan C Houweling, Carol Ann Remme, Coert J Zuurbier, Diederik W D Kuster, Jolanda van der Velden
Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors. Cardiovascular research 120 (3) (2024)
Paul J M Wijnker, Rafeeh Dinani, Nico C van der Laan, Sila Algül, Bjorn C Knollmann, Arjan C Houweling, Carol Ann Remme, Coert J Zuurbier, Diederik W D Kuster, Jolanda van der Velden
Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors. Cardiovascular research 120 (3) (2024)
Giovanna Nasilli, Arjan C Houweling, Molly O'Reilly, Loukia Yiangou, Richard P Davis, Simona Casini, Carol Ann Remme
Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Biomedicines 12 (6) (2024)
Ingmar S Plijter, Arjan C Houweling, Ronald Wilders
The Antidepressant Paroxetine Reduces the Cardiac Sodium Current. International journal of molecular sciences 24 (3) (2023)
Lixia Jia, Marieke W Veldkamp, Arjan C Houweling, Hanno L Tan
The opioid tramadol blocks the cardiac sodium channel Nav1.5 in HEK293 cells. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
Lixia Jia, Arjan C Houweling, Hanno L Tan
The Anti-Epileptic Drugs Lamotrigine and Valproic Acid Reduce the Cardiac Sodium Current. Biomedicines 11 (2) (2023)
Ingmar S Plijter, Arjan C Houweling, Ronald Wilders
The Antidepressant Paroxetine Reduces the Cardiac Sodium Current. International journal of molecular sciences 24 (3) (2023)
Phong D Nguyen, Iris Gooijers, Giulia Campostrini, Arjan C Houweling, Hessel Honkoop, Mara Bouwman, Dennis E M de Bakker, Tim Koopmans, Aryan Vink, Gerda E M Lamers, Avraham Shakked, Jonas Mars, Adriaan A Mulder, Sonja Chocron, Kerstin Bartscherer, Eldad Tzahor, Christine L Mummery, Teun P de Boer, Milena Bellin, Jeroen Bakkers
Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration. Science (New York, N.Y.) 380 (6646) (2023)
Ingmar S Plijter, Arjan C Houweling, Ronald Wilders
The Antidepressant Paroxetine Reduces the Cardiac Sodium Current. International journal of molecular sciences 24 (3) (2023)
Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arjan C Houweling, Bastiaan J D Boukens, Vincent M Christoffels
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility. eLife 12 (2023)
Phong D Nguyen, Iris Gooijers, Giulia Campostrini, Arjan C Houweling, Hessel Honkoop, Mara Bouwman, Dennis E M de Bakker, Tim Koopmans, Aryan Vink, Gerda E M Lamers, Avraham Shakked, Jonas Mars, Adriaan A Mulder, Sonja Chocron, Kerstin Bartscherer, Eldad Tzahor, Christine L Mummery, Teun P de Boer, Milena Bellin, Jeroen Bakkers
Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration. Science (New York, N.Y.) 380 (6646) (2023)
Arjan C Houweling, Ronald Wilders
Human Sinoatrial Node Pacemaker Activity: Role of the Slow Component of the Delayed Rectifier K + Current, I Ks . International journal of molecular sciences 24 (8) (2023)
David Y Chiang, Arjan C Houweling, Rachelle Victorio, Boris I Shneyer, Babet van der Vaart, Mariam Jouni, Nakul Narendran, Ashmita Kc, James R Sampognaro, Franki Vetrano-Olsen, John S Oh, Eva Buys, Berend de Jonge, Disheet A Shah, Tuomas O Kiviniemi, Maged M Costantine, Connie R Bezzina, Anna Akhmanova, Calum A MacRae
The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. Circulation research (2023)
Giovanna Nasilli, Loukia Yiangou, Chiara Palandri, Elisabetta Cerbai, Richard P Davis, Arjan C Houweling, Simona Casini, Carol Ann Remme
Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 25 (6) (2023)
Phong D Nguyen, Iris Gooijers, Giulia Campostrini, Arjan C Houweling, Hessel Honkoop, Mara Bouwman, Dennis E M de Bakker, Tim Koopmans, Aryan Vink, Gerda E M Lamers, Avraham Shakked, Jonas Mars, Adriaan A Mulder, Sonja Chocron, Kerstin Bartscherer, Eldad Tzahor, Christine L Mummery, Teun P de Boer, Milena Bellin, Jeroen Bakkers
Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration. Science (New York, N.Y.) 380 (6646) (2023)
Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arjan C Houweling, Bastiaan J D Boukens, Vincent M Christoffels
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility. eLife 12 (2023)
Ingmar S Plijter, Arjan C Houweling, Ronald Wilders
The Antidepressant Paroxetine Reduces the Cardiac Sodium Current. International journal of molecular sciences 24 (3) (2023)
Arjan C Houweling, Ronald Wilders
Human Sinoatrial Node Pacemaker Activity: Role of the Slow Component of the Delayed Rectifier K + Current, I Ks . International journal of molecular sciences 24 (8) (2023)
Arjan C Houweling, Ronald Wilders
The Action Potential Clamp Technique as a Tool for Risk Stratification of Sinus Bradycardia Due to Loss-of-Function Mutations in HCN4: An In Silico Exploration Based on In Vitro and In Vivo Data. Biomedicines 11 (9) (2023)
Giovanna Nasilli, Loukia Yiangou, Chiara Palandri, Elisabetta Cerbai, Richard P Davis, Arjan C Houweling, Simona Casini, Carol Ann Remme
Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 25 (6) (2023)
Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arjan C Houweling, Bastiaan J Boukens, Vincent M Christoffels
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility. eLife 12 (2023)
Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arjan C Houweling, Bastiaan J D Boukens, Vincent M Christoffels
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility. eLife 12 (2023)
Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arjan C Houweling, Bastiaan J D Boukens, Vincent M Christoffels
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility. eLife 12 (2023)
Arjan C Houweling, Ronald Wilders
Human Sinoatrial Node Pacemaker Activity: Role of the Slow Component of the Delayed Rectifier K + Current, I Ks . International journal of molecular sciences 24 (8) (2023)
Lixia Jia, Arjan C Houweling, Hanno L Tan
The Anti-Epileptic Drugs Lamotrigine and Valproic Acid Reduce the Cardiac Sodium Current. Biomedicines 11 (2) (2023)
Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arjan C Houweling, Bastiaan J D Boukens, Vincent M Christoffels
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility. eLife 12 (2023)
Anne Kayser, Sven Dittmann, Tomo Šarić, Giulia Mearini, Arjan C Houweling, Eric Schulze-Bahr
The W101C KCNJ5 Mutation Induces Slower Pacing by Constitutively Active GIRK Channels in hiPSC-Derived Cardiomyocytes. International journal of molecular sciences 24 (20) (2023)
Lixia Jia, Arjan C Houweling, Hanno L Tan
The Anti-Epileptic Drugs Lamotrigine and Valproic Acid Reduce the Cardiac Sodium Current. Biomedicines 11 (2) (2023)
Giulia Campostrini, Georgios Kosmidis, Dorien Ward-van Oostwaard, Richard P Davis, Loukia Yiangou, Daniele Ottaviani, Christiaan C Veerman, Hailiang Mei, Valeria V Orlova, Arthur A M Wilde, Connie R Bezzina, Arjan C Houweling, Christine L Mummery, Milena Bellin
Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia. Cardiovascular research (2022)
Alexandra Wiesinger, Jiuru Li, Lianne Fokkert, Priscilla Bakker, Arjan C Houweling, Vincent M Christoffels, Gerard J J Boink, Harsha D Devalla
A single cell transcriptional roadmap of human pacemaker cell differentiation. eLife 11 (2022)
Lucía Cócera-Ortega, Ronald Wilders, Selina C Kamps, Benedetta Fabrizi, Irit Huber, Ingeborg van der Made, Anouk van den Bout, Dylan K de Vries, Lior Gepstein, Arjan C Houweling, Yigal M Pinto, Anke J Tijsen
shRNAs Targeting a Common KCNQ1 Variant Could Alleviate Long-QT1 Disease Severity by Inhibiting a Mutant Allele. International journal of molecular sciences 23 (7) (2022)
Julien Barc, Rafik Tadros, Charlotte Glinge, David Y Chiang, Mariam Jouni, Floriane Simonet, Sean Joseph Jurgens, Manon Baudic, Michele Nicastro, Franck Potet, Joost A Offerhaus, Roddy Walsh, Seung Hoan Choi, Arjan C Houweling, Yuka Mizusawa, Soraya Anys, Damien Minois, Marine Arnaud, Josselin Duchateau, Yanushi D Wijeyeratne, Alison Muir, Michael Papadakis, Silvia Castelletti, Margherita Torchio, Cristina Gil Ortuño, Javier Lacunza, Daniela Francesca Giachino, Natascia Cerrato, Raphaël P Martins, Òscar Campuzano, Sonia Van Dooren, Aurélie Thollet, Florence Kyndt, Andrea Mazzanti, Nicolas Clémenty, Arnaud Bisson, Anniek Corveleyn, Birgit Stallmeyer, Sven Dittmann, Johan Saenen, Antoine Noël, Shohreh Honarbakhsh, Boris Rudic, Halim Marzak, Matthew K Rowe, Claire Federspiel, Sophie Le Page, Leslie Placide, Antoine Milhem, Hector Barajas-Martinez, Britt-Maria Beckmann, Ingrid P Krapels, Johannes Steinfurt, Bo Gregers Winkel, Reza Jabbari, Moore B Shoemaker, Bas J Boukens, Doris Škorić-Milosavljević, Hennie Bikker, Federico Manevy, Peter Lichtner, Marta Ribasés, Thomas Meitinger, Martina Müller-Nuraysid, null null, Jan Herman Veldink, Leonard H van den Berg, Philip Van Damme, Daniele Cusi, Chiara Lanzani, Sidwell Rigade, Eric Charpentier, Estelle Baron, Stéphanie Bonnaud, Simon Lecointe, Audrey Donnart, Hervé Le Marec, Stéphanie Chatel, Matilde Karakachoff, Stephane Bezieau, Barry London, Jacob Tfelt-Hansen, Dan Roden, Katja E Odening, Marina Cerrone, Larry A Chinitz, Paul G Volders, Maarten P van den Berg, Gabriel Laurent, Laurence Faivre, Charles Antzelevitch, Stefan Kääb, Alain Al Arnaout, Jean-Marc Dupuis, Jean-Luc Pasquie, Olivier Billon, Jason D Roberts, Laurence Jesel, Martin Borggrefe, Pier D Lambiase, Jacques Mansourati, Bart Loeys, Antoine Leenhardt, Pascale Guicheney, Philippe Maury, Eric Schulze-Bahr, Tomas Robyns, Jeroen Breckpot, Dominique Babuty, Silvia G Priori, Carlo Napolitano, null null, Carlos De Asmundis, Pedro Brugada, Ramon Brugada, Elena Arbelo, Josep Brugada, Philippe Mabo, Nathalie Behar, Carla Giustetto, Maria Sabater Molina, Juan R Gimeno, Can Hasdemir, Peter J Schwartz, Lia Crotti, Pascal P McKeown, Sanjay Sharma, Elijah R Behr, Michel Haissaguerre, Frédéric Sacher, Caroline Rooryck, Hanno L Tan, Carol A Remme, Pieter G Postema, Mario Delmar, Patrick T Ellinor, Steven A Lubitz, Jean-Baptiste Gourraud, Michael W T Tanck, Alfred L George, Calum A MacRae, Maged M Costantine, Christian Dina, Vincent Probst, Arthur A Wilde, Jean-Jacques Schott, Richard Redon, Connie R Bezzina
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nature genetics 54 (3) (2022)
Arjan C Houweling, Illés J Doszpod, Isabella Mengarelli, Tibor Magyar, Alexandra Polyák, Bence Pászti, Igor R Efimov, Ronald Wilders, István Koncz
Acetylcholine Reduces L-Type Calcium Current without Major Changes in Repolarization of Canine and Human Purkinje and Ventricular Tissue. Biomedicines 10 (11) (2022)
Niels Harlaar, Sven O Dekker, Juan Zhang, Rebecca R Snabel, Marieke W Veldkamp, Arjan C Houweling, Carla Cofiño Fabres, Verena Schwach, Lente J S Lerink, Mathilde R Rivaud, Aat A Mulder, Willem E Corver, Marie-José T H Goumans, Dobromir Dobrev, Robert J M Klautz, Martin J Schalij, Gert Jan C Veenstra, Robert Passier, Thomas J van Brakel, Daniël A Pijnappels, Antoine A F de Vries
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation. Nature biomedical engineering 6 (4) (2022)
Antoinette F van Ouwerkerk, Fernanda M Bosada, Karel van Duijvenboden, Arjan C Houweling, Koen T Scholman, Vincent Wakker, Cornelis P Allaart, Jae Sun Uhm, Inge B Mathijssen, Ton Baartscheer, Alex V Postma, Phil Barnett, Bastiaan J Boukens, Vincent M Christoffels
Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction. Circulation 145 (8) (2022)
István Koncz, Arjan C Houweling, Michele Nicastro, Ronald Wilders, Tamás Árpádffy-Lovas, Tibor Magyar, Noémi Tóth, Norbert Nagy, Micah Madrid, Zexu Lin, Igor R Efimov
Acetylcholine Reduces I Kr and Prolongs Action Potentials in Human Ventricular Cardiomyocytes. Biomedicines 10 (2) (2022)
Charlotte D Koopman, Jessica De Angelis, Swati P Iyer, Arjan C Houweling, Jason Da Silva, Geza Berecki, Angela Jeanes, Gregory J Baillie, Scott Paterson, Veronica Uribe, Ophelia V Ehrlich, Samuel D Robinson, Laurence Garric, Steven Petrou, Cas Simons, Irina Vetter, Benjamin M Hogan, Teun P de Boer, Jeroen Bakkers, Kelly A Smith
The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm. Proceedings of the National Academy of Sciences of the United States of America 118 (9) (2021)
Sarah M Kamel, Chantal J M van Opbergen, C D Koopman, Arjan C Houweling, B J D Boukens, B de Jonge, Yeszamin L Onderwater, E van Alebeek, S Chocron, C Polidoro Pontalti, Wout J Weuring, M A Vos, Teun P de Boer, Toon A B van Veen, Jeroen Bakkers
Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy. Nature communications 12 (1) (2021)
Rupamanjari Majumder, Tim De Coster, Nina Kudryashova, Arjan C Houweling, Ivan V Kazbanov, Balázs Ördög, Niels Harlaar, Ronald Wilders, Antoine Af de Vries, Dirk L Ypey, Alexander V Panfilov, Daniel A Pijnappels
Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating. eLife 9 (2020)
Suzan J G Knottnerus, Isabella Mengarelli, Rob C I Wüst, Antonius Baartscheer, Jeannette C Bleeker, Ruben Coronel, Sacha Ferdinandusse, Kaomei Guan, Lodewijk IJlst, Wener Li, Xiaojing Luo, Vincent M Portero, Ying Ulbricht, Gepke Visser, Ronald J A Wanders, Frits A Wijburg, Arjan C Houweling, Riekelt H L Houtkooper, Connie R Bezzina
Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates. International journal of molecular sciences 21 (7) (2020)
Arjan C Houweling, Elisabeth M Lodder, Ronald Wilders
Aquaporin Channels in the Heart-Physiology and Pathophysiology. International journal of molecular sciences 20 (8) (2019)
Anna M D Végh, A Dénise den Haan, Lucía Cócera Ortega, Arjan C Houweling, Joost P G Sluijter, Diane Bakker, Shirley van Amersfoorth, Toon A B van Veen, Mischa Klerk, Jurgen Seppen, Jacques M T de Bakker, Vincent M Christoffels, Dirk Geerts, Marie José T H Goumans, Hanno L Tan, Gerard J J Boink
Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing. Molecules (Basel, Switzerland) 24 (1) (2019)
Roberto Quaranta, Jakob Fell, Frank Rühle, Jyoti Rao, Ilaria Piccini, Marcos J Araúzo-Bravo, Arjan C Houweling, Monika Stoll, Boris Greber
Revised roles of ISL1 in a hES cell-based model of human heart chamber specification. eLife 7 (2018)