A specific immunoassay for detection of feline kidney injury molecule 1.

S Karlyn BlandMary Ellen ClarkOlivier CôtéDorothee Bienzle

Published in: Journal of feline medicine and surgery (2018)

A practical patient-side assay for detection of KIM-1 in feline urine has been developed. Preliminary results show marked though transient increases in cats with sepsis and urethral obstruction-associated AKI, and expression in injured tubules. Although initial data indicating that the LFA is sensitive and specific for KIM-1 in cats with AKI are promising, values associated with different types of injury, urine collection, urine storage and specific gravity need to be investigated.

Keyphrases

acute kidney injury
label free
poor prognosis
loop mediated isothermal amplification
intensive care unit
real time pcr
case report
high throughput
electronic health record
machine learning
sensitive detection
high resolution
quantum dots