A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model.

Qiaofeng LiTaijin LanSonghua HeWeiwei ChenXiaolan LiWeiquan ZhangYing LiuQiuping ZhangXin ChenYaoyao HanZhiheng SuDan ZhuHongwei Guo

Published in: Chinese medicine (2021)

LFG can reduce the blood pressure in SHR model, which might be attributed to increasing the NO level in serum for promoting vasodilation via upregulating SRC expression level and activating the PI3K-AKT-NOS3 signaling pathway. Nicotinic acid might be the potential compound for LFG antihypertensive effect.

Keyphrases

blood pressure
signaling pathway
hypertensive patients
heart rate
poor prognosis
pi k akt
epithelial mesenchymal transition
tyrosine kinase
nitric oxide synthase
induced apoptosis
nitric oxide
oxidative stress
adipose tissue
risk assessment
preterm birth