Automated Synthesis and Initial Evaluation of (4'-Amino-5',8'-difluoro-1'H-spiro[piperidine-4,2'-quinazolin]-1-yl)(4-[18F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase.
Skye Hsin-Hsien YehWen-Sheng HuangChuang-Hsin ChiuChuan-Lin ChenHui-Ting ChenDae Yoon ChiZhengxing GeTsung-Hsun YuPao-Yeh WangYu-Yeh KuoChun-Tse HungGeng-Ying LiChi-Wei ChangPublished in: Molecular imaging (2021)
An automated robotic method was established for radiosynthesis of [18F]FBAT, and the preliminary in vitro and in vivo results demonstrated the feasibility of detecting iNOS activity/expression in LPS-treated neuroinflammation by noninvasive imaging with [18F]FBAT PET/MRI.
Keyphrases
- nitric oxide synthase
- pet imaging
- nitric oxide
- contrast enhanced
- computed tomography
- positron emission tomography
- pet ct
- poor prognosis
- magnetic resonance imaging
- high resolution
- inflammatory response
- traumatic brain injury
- machine learning
- deep learning
- lipopolysaccharide induced
- magnetic resonance
- minimally invasive
- robot assisted
- cognitive impairment
- mass spectrometry
- single cell