Recent advances on the roles of LncRNAs in cardiovascular disease.
Yexian FangYuerong XuRunze WangLang HuDong GuoFeng XueWangang GuoDongwei ZhangJianqiang HuYan LiWei ZhangMingming ZhangPublished in: Journal of cellular and molecular medicine (2020)
Cardiovascular diseases are a main cause of mortality whose prevalence continues to increase worldwide. Long non-coding RNAs (lncRNAs) regulate a variety of biological processes by modifying and regulating transcription of coding genes, directly binding to proteins and even coding proteins themselves. LncRNAs play key roles in the occurrence and development of myocardial infarction, heart failure, myocardial hypertrophy, arrhythmias and other pathological processes that significantly affect the prognosis and survival of patients with cardiovascular diseases. We here review the latest research on lncRNAs in cardiovascular diseases as a basis to formulate future research on prevention and treatment of cardiovascular diseases.
Keyphrases
- cardiovascular disease
- heart failure
- genome wide identification
- long non coding rna
- cardiovascular events
- genome wide analysis
- left ventricular
- network analysis
- cardiovascular risk factors
- type diabetes
- transcription factor
- risk factors
- poor prognosis
- risk assessment
- coronary artery disease
- combination therapy
- metabolic syndrome
- atrial fibrillation
- congenital heart disease
- cardiac resynchronization therapy
- smoking cessation