Role of Leptin/Osteopontin Axis in the Function of Eosinophils in Allergic Rhinitis with Obesity.
Wenlong LiuQingxiang ZengYanqiu ChenRen Zhong LuoPublished in: Mediators of inflammation (2018)
Our results suggested that in an obese state, upregulation of leptin and OPN regulates apoptosis, adhesion, migration, and activation of eosinophils, and this process may be mediated by the PI3K and anti-α4 pathways.
Keyphrases
- allergic rhinitis
- weight loss
- metabolic syndrome
- type diabetes
- insulin resistance
- oxidative stress
- adipose tissue
- endoplasmic reticulum stress
- bariatric surgery
- cell cycle arrest
- cell death
- poor prognosis
- cell proliferation
- weight gain
- high fat diet induced
- biofilm formation
- obese patients
- escherichia coli
- cystic fibrosis
- pseudomonas aeruginosa
- staphylococcus aureus
- long non coding rna
- cell migration