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FOXO1 inhibition prevents renal ischemia-reperfusion injury via cAMP-response element binding protein/PPAR-γ coactivator-1α-mediated mitochondrial biogenesis.

Di WangYanqing WangXiantong ZouYundi ShiQian LiuTianru HuyanJing SuQi WangFengxue ZhangXuejun LiLu Tie
Published in: British journal of pharmacology (2019)
These findings suggested that FOXO1 was critical to maintain mitochondrial function in renal tubular epithelial cells and FOXO1 may serve as a therapeutic target for pharmacological intervention in renal I/R injury.
Keyphrases
  • binding protein
  • transcription factor
  • ischemia reperfusion injury
  • signaling pathway
  • oxidative stress
  • pi k akt
  • randomized controlled trial
  • type diabetes
  • mouse model
  • cell proliferation