FOXO1 inhibition prevents renal ischemia-reperfusion injury via cAMP-response element binding protein/PPAR-γ coactivator-1α-mediated mitochondrial biogenesis.

Di WangYanqing WangXiantong ZouYundi ShiQian LiuTianru HuyanJing SuQi WangFengxue ZhangXuejun LiLu Tie

Published in: British journal of pharmacology (2019)

These findings suggested that FOXO1 was critical to maintain mitochondrial function in renal tubular epithelial cells and FOXO1 may serve as a therapeutic target for pharmacological intervention in renal I/R injury.

Keyphrases

binding protein
transcription factor
ischemia reperfusion injury
signaling pathway
oxidative stress
pi k akt
randomized controlled trial
type diabetes
mouse model
cell proliferation