H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development.

Yue YuXinjie LiRui JiaoYang LuXuan JiangXin Li

Published in: Cell & bioscience (2023)

These findings suggest that H3K27me3-H3K4me1 transition plays a key role in lineage differentiation by regulating the expression of tissue specific genes, and H3K4me1 pattern in bivalent promoters could be modulated by LSD1 via interacting with PRC2.

Keyphrases

cell fate
single cell
poor prognosis
genome wide
binding protein
gene expression
protein kinase
long non coding rna
transcription factor